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Managing insulin resistance: role of liraglutide

Authors Kalra S, Kalra B, Kumar S, Sharma A

Published 24 June 2010 Volume 2010:2 Pages 131—134


Review by Single anonymous peer review

Peer reviewer comments 3

Sanjay Kalra1, Bharti Kalra1, Satish Kumar2, Amit Sharma1

1Department of Endocrinology, Bharti Hospital, Karnal, India; 2Department of Clinical Operations, Excel Life Sciences, Noida, India

Abstract: Diabetes mellitus is part of the insulin resistance syndrome, which includes hypertension, dyslipidemia, and obesity as its other components. Conversely, insulin resistance is a major pathophysiologic factor in the development of type 2 diabetes. It makes sense, therefore, to choose an anti-diabetic medication that acts on insulin resistance and its clinical components, while having anti-hyperglycemic effects as well. This review discusses the non-glycemic, or extra-pancreatic effects, including insulin sensitization, of liraglutide, a novel GLP-1 analog.

Keywords: liraglutide, GLP-1 analog, weight modulation, systolic blood pressure, cardioprotection, insulin resistance

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