Back to Journals » Lung Cancer: Targets and Therapy » Volume 1 » Default

Maintenance therapy for metastatic non-small-cell lung cancer – the role of pemetrexed

Authors Katz Y, Somer R

Published 12 April 2010 Volume 2010:1 Pages 1—7

DOI https://doi.org/10.2147/LCTT.S7105

Review by Single-blind

Peer reviewer comments 3


Youval Katz, Robert A Somer

Cooper University Hospital, Cooper Cancer Institute, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, Camden, New Jersey, USA

Abstract: Over the last several years, we have greatly enhanced our understanding of tumor biology and have now integrated novel and molecular-targeted therapies into front-line treatment for locally advanced and metastatic non-small-cell lung cancer (NSCLC). Despite all the recent advances, the improvement in survival outcomes for these patients has been measured in weeks compared to historical controls. Clinical researchers continue to search for the silver bullet that will allow oncologists to treat lung cancer as a chronic illness and prolong life well beyond the statistical barrier of 1 year for these patients. In that vein, maintenance therapy is emerging as a new treatment option in the metastatic setting. However, there is much controversy over the validity and cost-effectiveness of this modality. Recently, a phase III trial of pemetrexed maintenance versus best supportive care in the setting of metastatic NSCLC following non-progression after 4 cycles of platinum-based doublet therapy showed significant survival outcomes of the treatment group. This article will review the current available treatment options in metastatic NSCLC, including maintenance regimens, with particular  attention paid to the recent pemetrexed study.
Keywords: non-small-cell lung cancer, pemetrexed, maintenance therapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]