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LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α

Authors Yu H, Zhou W, Yan W, Xu Z, Xie Y, Zhang P

Received 18 February 2019

Accepted for publication 24 May 2019

Published 20 September 2019 Volume 2019:14 Pages 1663—1669

DOI https://doi.org/10.2147/CIA.S205796

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Haotao Yu, Wei Zhou, Weiming Yan, Zhongqi Xu, Yinhao Xie, Ping Zhang

Department of Orthopedics, Division 1, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province 510000, People’s Republic of China

Correspondence: Ping Zhang
Department of Orthopedics, Division 1, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Street, Liwan District, Guangzhou City, Guangdong Province 510000, People’s Republic of China
Tel/Fax +86 0 208 134 6935
Email vt94225@163.com

Purpose: In this study, we aimed to investigate the role of lncRNA cancer susceptibility 11 (CASC11) and tumor necrosis factor (TNF-α) in postmenopausal osteoporosis (POP).
Methods and materials: POP patients and healthy controls were included in this study and levels of CASC11 and TNF-α in plasma of those participants were measured by qPCR and Western blot, respectively. ROC curve was used for diagnostic analysis. Patients were followed up for 2 years and the correlations between the levels of CASC11 and TNF-α and disease conditions were analyzed.
Results: We found that CASC11 and TNF-α were both upregulated in plasma of POP patients than in healthy controls. Plasma levels of CASC11 and TNF-α were positively correlated in both POP patients and in healthy controls. Upregulation of CASC11 and TNF-α distinguished POP patients from healthy controls. Treatment and follow-up study showed that high CASC11 levels were significantly correlated with prolonged treatment course and high recurrence rate. Plasma levels of CASC11 and TNF-α decreased after treatment. CASC11 overexpression led to upregulated TNF-α in osteoclasts.
Conclusion: CASC11 is upregulated in POP and is correlated with TNF-α.

Keywords: postmenopausal osteoporosis, CASC11, TNF-α, osteoclasts

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