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Liposomal curcumin and its application in cancer

Authors Feng T, Wei Y, Lee RJ, Zhao L

Received 14 January 2017

Accepted for publication 12 June 2017

Published 21 August 2017 Volume 2017:12 Pages 6027—6044

DOI https://doi.org/10.2147/IJN.S132434

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lakshmi Kiran Chelluri

Peer reviewer comments 4

Editor who approved publication: Dr Lei Yang


Ting Feng,1,* Yumeng Wei,1,* Robert J Lee,2 Ling Zhao1

1Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA

*These authors contributed equally to this work

Abstract: Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

Keywords: curcumin, liposomes, drug delivery, bioavailability, cancer
 

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