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Prognostic value of IGF-1R expression in bone and soft tissue sarcomas: comments on a meta-analysis by Liang et al

Authors Tu C, He J, Li Z

Received 11 January 2016

Accepted for publication 11 January 2016

Published 5 April 2016 Volume 2016:9 Pages 2017—2018

DOI https://doi.org/10.2147/OTT.S104004

Checked for plagiarism Yes

Editor who approved publication: Professor Daniele Santini


Chao Tu,1 Jieyu He,2 Zhihong Li3

1Department of Geriatric Surgery, 2Department of Geriatrics, 3Department of Orthopedics and Institute of Senile and Aging Diseases, The Second Xiangya Hospital of Central South University, Changsha, People’s Republic of China


Recently, we read with deep interest a meta-analysis by Liang et al entitled “Prognostic value of IGF-1R expression in bone and soft tissue sarcomas: a meta-analysis” published in OncoTargets and Therapy. In this article, the investigators systematically reviewed the trials on the effects of IGF-1R expression in various bone and soft tissue sarcomas (BSTSs) and performed a meta-analysis. They reached an important conclusion that elevated IGF-1R expression was associated with poor overall survival in BSTS patients. Furthermore, subgroup analysis revealed that IGF-1R level was negatively correlated with prognosis in osteosarcoma but not significantly associated with Ewing’s sarcoma. We sincerely appreciate the tremendous effort made by the investigators. Nevertheless, before their results can be accepted, some worthwhile issues need to be addressed first.

View original article by Liang et al.

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