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Treatment challenges for community oncologists treating postmenopausal women with endocrine-resistant, hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer

Authors Abdel-Razeq H

Received 15 July 2016

Accepted for publication 30 August 2016

Published 20 October 2016 Volume 2016:8 Pages 127—128

DOI https://doi.org/10.2147/CMAR.S117274

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Kenan Onel


Hikmat Abdel-Razeq

Department of Internal Medicine, King Hussein Cancer Center, Amman, Jordan

I read with great interest the review written elegantly by Gradishar addressing the challenges that community oncologists face in treating postmenopausal women with endocrine-resistant, hormone receptor-positive, human epidermal growth factor receptor-2 (HER2)-negative advanced breast cancer in your journal.1
As the author correctly stated, resistance to endocrine therapy in women with hormone receptor-positive disease is very frequent and almost inevitable.
Understanding the multiple known mechanisms for endocrine resistance has helped physicians and researchers target these pathways.2 Many of the recently introduced drugs, such as the mTOR inhibitor everolimus3 and the cyclin-dependent kinase (CDK 4/6) inhibitor palbociclib,4 are in clinical practice and have been already incorporated in international guidelines.5

View original paper by Gradishar.

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