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Choroidal Thickness and microRNA146 in Lupus Nephritis Patients [Letter]

Authors Capasso L, Gioia M, De Bernardo M, Rosa N

Received 27 August 2020

Accepted for publication 2 September 2020

Published 22 September 2020 Volume 2020:14 Pages 2773—2774

DOI https://doi.org/10.2147/OPTH.S279039

Checked for plagiarism Yes

Editor who approved publication: Dr Scott Fraser


Luigi Capasso, Marco Gioia, Maddalena De Bernardo, Nicola Rosa

Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi, Salerno, Italy

Correspondence: Maddalena De Bernardo
Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, via Salvador Allende, Baronissi 84081, SA, Italy
Tel +39089 965063
Fax +39 089672407
Email mdebernardo@unisa.it


We have read with great interested the article by Salah et al,1 concerning the macular choroidal thickness (CT) evaluation in patients with lupus nephritis, compared to both non-nephritic patients and healthy  subjects. 
 
We congratulate the authors for their outstanding paper, but we would like to make some comments.
 
View the original paper by Salah and colleagues

Dear editor

We have read with great interested the article by Salah et al,1 concerning the macular choroidal thickness (CT) evaluation in patients with lupus nephritis, compared to both non-nephritic patients and healthy subjects.

We congratulate the authors for their outstanding paper, but we would like to make some comments.

In agreement with the article by Barteselli et al,2 cited by the authors, we consider that CT could be influenced by several factors like age, axial length (AL), sex,3,4 but unfortunately, the authors did not evaluate AL differences among the examined groups; therefore, the CT impact of these data is not known.

Moreover, in the methods section, the authors described a good technique to measure CT, and we agree that the posterior edge of retinal pigment epithelium (RPE) can be easily identified.5

Nevertheless, according to Figure 1, it seems that they failed to make a precise measurement, making their results questionable.

In fact, from this figure, it appears that the sub-foveal CT was measured from the Outer photoreceptor segment, whereas nasal and temporal CT were even more difficult to identify, but it seems that they were measured from the area between the interdigitation zone and Bruch’s membrane. In case of future works on this topic, we would like to suggest paying more attention to the line drawing between RPE and the choroid-scleral junction to obtain more consistent CT measurements.

Disclosure

The authors report no conflicts of interest for this communication.

References

1. Hassan Salah S, Makled HS, ElMekawey H, et al. Choroidal thickness and microRNA146 in lupus nephritis patients. Clin Ophthalmol. 2020;14:1503–1510. doi:10.2147/OPTH.S254288

2. Barteselli G, Chhablani J, El-Emam S, et al. Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis. Ophthalmology. 2012;119:2572–2578. doi:10.1016/j.ophtha.2012.06.065

3. De Bernardo M, Salerno G, Cornetta P, Rosa N. Axial length shortening after cataract surgery: new approach to solve the question. Transl Vis Sci Technol. 2018;7:34. doi:10.1167/tvst.7.6.34

4. Li XQ, Larsen M, Munch IC. Subfoveal choroidal thickness in relation to sex and axial length in 93 Danish university students. Invest Ophthalmol Vis Sci. 2011;52(11):8438. doi:10.1167/iovs.11-8108

5. De Bernardo M, Altieri V, Coppola A, Gioia M, Rosa N. Choroidal evaluation in patients under alpha-lytic therapy. Graefes Arch Clin Exp Ophthalmol. 2020. doi:10.1007/s00417-020-04907-1

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