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Knee osteoarthritis: pathophysiology and current treatment modalities

Authors Mora JC, Przkora R, Cruz-Almeida Y

Received 4 June 2018

Accepted for publication 7 August 2018

Published 5 October 2018 Volume 2018:11 Pages 2189—2196

DOI https://doi.org/10.2147/JPR.S154002

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr E Alfonso Romero-Sandoval


Juan C Mora,1 Rene Przkora,1 Yenisel Cruz-Almeida2

1Department of Anesthesiology, Division of Pain Medicine, University of Florida, Gainesville, FL, USA; 2Department of Aging and Geriatric Research, Institute on Aging, Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA

Abstract: For decades, multiple attempts to fully understand knee osteoarthritis pathophysiology and natural history have been attempted. Despite the extensive amount of research regarding this topic, there are still marked controversies. This multifactorial condition gets influenced by local, systemic, and external factors and its progression and/or response to treatments widely varies from patient to patient. Multiple therapies have been studied in the past, low impact physical activity seems to be supported by all the current medical societies while other interventions have shown conflicting findings. Newer therapies and routes of administration are under investigation and some of them have shown promising preliminary reports. This review intends to give an overview of the current knowledge of pathophysiology and non-surgical therapies available for knee osteoarthritis.

Keywords: knee osteoarthritis, cartilage degeneration, non-inflammatory arthritis, intra-articular injections, corticosteroids

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