Back to Journals » International Medical Case Reports Journal » Volume 13

Juvenile Xanthogranuloma: Case Report and Literature Review

Authors Vahabi-Amlashi S, Hoseininezhad M, Tafazzoli Z

Received 26 November 2019

Accepted for publication 14 February 2020

Published 25 February 2020 Volume 2020:13 Pages 65—69

DOI https://doi.org/10.2147/IMCRJ.S240115

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Ronald Prineas


Sadegh Vahabi-Amlashi, Masoumeh Hoseininezhad, Zahra Tafazzoli

Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence: Zahra Tafazzoli
Department of Dermatology, Imam Reza Hospital, Ibn e Sina Street, Mashhad, Iran
Tel +98 91 51885344
Fax +98 51 38583845
Email [email protected]

Abstract: Juvenile Xanthogranuloma (JXG) is a relatively uncommon non-Langerhans cell histiocytosis, which often occurs at an early age and is usually asymptomatic. Herein, we present the case of a 17-year-old man with numerous asymptomatic yellow-brown papulonodular lesions with a symmetric distribution on upper and lower extremities, face, and trunk, developed over the past 4 years. In the histopathologic examination, histiocytes with a Touton-like appearance were observed in favor of xanthogranuloma. The patient was treated with isotretinoin 20 mg daily for 2 months, which surprisingly led to the progression of lesions and thus was discontinued. Although JXG may cause severe morbidities in some circumstances, it is a self-limiting benign disorder and patients should be assured regarding the benign self-regressive nature of the disease.

Keywords: non-langerhans-cell histiocytosis, isotretinoin, adult, Juvenile Xanthogranulomas

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]