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Juvenile Xanthogranuloma: Case Report and Literature Review

Authors Vahabi-Amlashi S, Hoseininezhad M, Tafazzoli Z

Received 26 November 2019

Accepted for publication 14 February 2020

Published 25 February 2020 Volume 2020:13 Pages 65—69


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Ronald Prineas

Sadegh Vahabi-Amlashi, Masoumeh Hoseininezhad, Zahra Tafazzoli

Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence: Zahra Tafazzoli
Department of Dermatology, Imam Reza Hospital, Ibn e Sina Street, Mashhad, Iran
Tel +98 91 51885344
Fax +98 51 38583845
Email [email protected]

Abstract: Juvenile Xanthogranuloma (JXG) is a relatively uncommon non-Langerhans cell histiocytosis, which often occurs at an early age and is usually asymptomatic. Herein, we present the case of a 17-year-old man with numerous asymptomatic yellow-brown papulonodular lesions with a symmetric distribution on upper and lower extremities, face, and trunk, developed over the past 4 years. In the histopathologic examination, histiocytes with a Touton-like appearance were observed in favor of xanthogranuloma. The patient was treated with isotretinoin 20 mg daily for 2 months, which surprisingly led to the progression of lesions and thus was discontinued. Although JXG may cause severe morbidities in some circumstances, it is a self-limiting benign disorder and patients should be assured regarding the benign self-regressive nature of the disease.

Keywords: non-langerhans-cell histiocytosis, isotretinoin, adult, Juvenile Xanthogranulomas

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