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Hypoxia


Prof. Dr. Katschinski

Institute of Cardiovascular Physiology, Georg August University Göttingen, Germany

Prof. Dr. Katschinski

Editor-in-Chief: Prof. Dr. Dörthe M. Katschinski

Prof. Dr. Dörthe M. Katschinski is Professor of Physiology and Director of the Institute of Cardiovascular Physiology at the Georg-August University Göttingen, Germany.

Prof. Dr. Katschinski received her MD and PhD in physiology in 1994 from the University of Lübeck medical faculty. She completed her residency in oncology in Lübeck and a fellowship at the Comprehensive Cancer Center, University of Wisconsin, USA.

Prof. Dr. Katschinski is serving as the Deputy Director of the Heart Center Göttingen, University of Göttingen, and she is co-chairing the European HypoxiaNet COST Action, a platform that coordinates and strengthens basic research on hypoxia signalling pathways, accelerating scientific progress on the levels of basic science, technology, pharmacology and translational medicine.

In her research Prof. Dr. Katschinski focuses on a detailed understanding of the mechanisms of hypoxia sensing, signalling and adaptation to exploit this signalling pathway for therapeutic applications in cardiovascular medicine and oncology.


Prof. Dr. Wenger

Institute of Physiology, University of Zurich, Switzerland

Prof. Dr. Wenger

Associate Editor: Prof. Dr. Roland Wenger

Prof. Dr. Wenger is Professor of Physiology and Director of the Institute of Physiology at the University of Zürich, Switzerland. He graduated in chemistry and received his diploma in biochemistry (1987) and PhD in molecular biology (1990) from the University of Bern (Switzerland). Following a post-doctoral fellowship of the Max-Planck-Society at the Max-Planck-Institute for Immunobiology (Freiburg, Germany) from 1990 to 1993, he became senior scientist at the Institute of Physiology, University of Zürich, where he habilitated and obtained his PhD in Physiology (1999). He was university lecturer at the University of Lübeck, Germany until 2001 and Associate Professor at the University of Leipzig, Germany until 2003, before he became full Professor of Physiology at the University of Zürich. He was Vice Dean of the Medical Faculty from 2007 to 2012.

Prof. Dr. Wenger chaired the HypoxiaNet COST Action of the European Community (2009-2013) and has been a management committee member of the COST Action Gasotransmitters since 2013. He is Associate Editor of BMC Physiology and Editorial Advisor of the Biochemical Journal. Prof. Dr. Wenger heads the Cellular Oxygen Physiology research group, which explores the molecular mechanisms and therapeutical consequences of cellular sensing, signaling and adaptation to changing oxygen availability.


Dr Evans

Department of Pharmacology, University of Illinois at Chicago, United States

Dr Evans

Launch Editor: Dr Colin Evans

Dr Evans obtained a BSc in Exercise Sciences from the University of Birmingham (2004-2006) and a PhD in Cardiovascular Medicine from King’s College London (2007-2010). His postdoctoral training was carried out with Prof Randall Johnson at the University of California San Diego and subsequently at the University of Cambridge (2011-2015). In 2016, Dr Evans was awarded a Parke Davis Fellowship by the University of Cambridge to continue his research as Visiting Scholar in the Center for Lung and Vascular Biology at the University of Illinois at Chicago. Dr Evans studies mechanisms that regulate the associations between hypoxia, thrombosis, and inflammatory vascular diseases. His sources of funding have included the British Heart Foundation, the British Society for Haematology, and Thrombosis UK. 


Editorial Board

Till Acker, Professor of Neuropathology, Institute of Neuropathology, University of Giessen, Germany. Research interests: Tumor microenvironment, tumor metabolism, tumor angiogenesis, aKG-dependent oxygenases.

Aida Bairam, Professor, Department of Pediatrics and Neonatology, Laval University, Canada

Gaetano Cairo, Professor of General Pathology, University of Milan, Italy. Research interests: Iron metabolism, hypoxia, HIF-1, erythropoietin, transferrin receptor, high altitude, hepcidin.

Yihai Cao, Professor, Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

William K. Chan, Department Chair and Professor, Department of Pharmaceutics & Medicinal Chemistry, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific Stockton, CA, USA. Research interests: Aryl hydrocarbon receptor signaling mechanisms.

Sean Colgan, Professor of Molecular Biology, University of Colorado School of Medicine, Colorado, USA

Claire Dubois, Professor, Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Sherbrooke University, Canada. Research interests: pH regulation, sodium/proton exchangers, hypoxia, transforming growth factor-beta, cancer biology, chemoresistance, chronic inflammation, rheumatoid arthritis.

Max Gassmann, Chairman, Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland

Norberto C. Gonzalez, Professor Emeritus, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA. Research interests: Systemic oxygen transport in acute and chronic hypoxia, at rest and during exercise; Mechanisms of altitude acclimatization; Hypoxia and inflammation; Hypoxia and the microcirculation; Respiratory effects of acute and chronic hypoxia; Cardiovascular effects of acute and chronic hypoxia.

Rodrigo Iturriaga, Professor, Faculty of Biological Sciences, P. Catholic University of Chile, Chile. Research interests: Carotid body physiology; Intermittent hypoxia; Autonomic and cardiorespiratory consequence of intermittent hypoxia (sleep apnea).

Thomas Kietzmann, Professor of Cell Biochemistry, University of Oulu, Finland. Research interests: Redox signaling, metabolism, kinases, ubiquitylation, coagulation, fibrinolysis.

Ho Jeong Kwon, Professor, Department of Biotechnology, Yonsei University, Seoul, South Korea

Wei Li, Professor, Director of GMCB Graduate Program, University of Southern California, Department of Dermatology and the USC/Norris Cancer Research Center, Los Angeles, CA, USA. Research interests: Hypoxia stress and exosome secretion; Hypoxia-driven exosome-mediated Hsp90a secretion; Signaling networks of hypoxia stress; IF-1a and exosome pathway; Hypoxia in wound healing and tumor progression; New therapeutic targets in HIF-1a pathway.

Jose Lopez-Barneo, Professor of Physiology and Director of the Institute of Biomedicine of Seville, Seville, Spain. Research interests: Acute oxygen sensing; hypoxia, arterial chemoreceptors; Carotid body; Adrenal medulla; Neurogenesis; Neurodegeneration; Neural stem cells; Ion channels; Mitochondria.

Eugenia B. Manukhina, Professor and Head, Laboratory of Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. Research interests: Adaptation to hypoxia, intermittent hypoxia conditioning, blood vessels, circulation, blood pressure, endothelium, endothelial dysfunction, nitric oxide, stress, post-traumatic stress disorder, myocardial infarction, Alzheimer's disease, cardiovascular risk factors.

Johanna Myllyharju, Professor of Molecular Biology, Scientific Director of Biocenter Oulu, Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland. Research interests: Key enzymes regulating hypoxia response and extracellular matrix synthesis; Prolyl 4-hydroxylases; Extracellular matrix field / Hypoxia sensing, signalling and adaptation; Hypoxia: Regulator aspects in cells, tissues and organisms.

Ken D. O’Halloran, Professor & Chair, Department of Physiology, School of Medicine, Western Gateway Building, Western Road, University College Cork, Ireland

Asher Ornoy, Professor of Anatomy, Embryology and Teratology, Hebrew University Hadassah Medical School, Israel. Research interests: Clinical teratology, diabetic embryopathy, oxidative stress as a cause of teratogenicity, hypoxia as a cause of teratogenicity; prenatal etiology of ASD (autism spectrum disorder).

Silvia Pastorekova, Professor, Head of the Department of Tumor Biology and Director of the Biomedical Research Center, Slovak Academy of Sciences, Slovak Republic.

Dan Peet, Associate Professor, Biochemistry; Head of Hypoxic Signaling Laboratory, School of Biological Sciences, University of Adelaide, Australia. Research interests: Understanding the molecular events within cells that underpin the genomic response to hypoxia; HIFs; Identification and characterisation of novel substrates of the oxygen-sensing hydroxylases; Cellular metabolism, specifically the unusual metabolism displayed by proliferating cells, especially cancer cells, that mimic quiescent cells in hypoxia; Photoreceptor cells in the retina, which also display cancer-like metabolism.

George Perry, Chief Scientist, Brain Health Consortium, Professor of Biology and Chemistry, College of Sciences, University of Texas at San Antonio, San Antonio, TX, USA. Research interests: Alzheimer’s disease, oxidative stress, metabolism, mitochondria, redox chemistry, iron, copper.

Kota V. Ramana, Professor, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA. Research interests: Oxidative stress, signal transduction, aldo-keto reductases, and inflammatory complications.

Professor Sir Peter Ratcliffe FRS, Director of the Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Head of Clinical Research at the Francis Crick Institute, London, Member of the Ludwig Institute for Cancer Research. Research interests: Hypoxia biology; Oxygen sensing; Prolyl hydroxylation; Oxygenases; Transcription; Signalling.

Olga V. Razorenova, Associate Professor, Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA. Research interests: Hypoxia, kidney cancer, breast cancer, VHL, HIF, p53, CDCP1, migration, invasion, lipid metabolism, metastasis.

Jean-Paul Richalet, Professor of Physiology at University Paris 13, France. Research interests: Physiology, hypoxia, altitude, exercise, cardiovascular and respiratory adaptation to hypoxia, acute mountain sickness, high altitude pulmonary and cerebral edema, training in hypoxia/altitude.

Darren Richard, Professor, Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec, Canada

Patrick Ronaldson, Associate Professor, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA. Research interests: Blood-Brain Barrier; Drug Delivery; Inflammation; Intracellular Signaling Pathways; Ischemic Stroke; Neurovascular Unit; Oxidative Stress; Transporters; Vascular Biology.

M. Celeste Simon, PhD, Scientific Director and Investigator, Abramson Family Cancer Research Institute; Arthur H. Rubenstein, MBBCh Professor, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Research interests: Influence of oxygen and nutrient availability on the tumor microenvironment; Metabolic exchanges between tumor parenchyma and stroma (i.e. epithelial cells, immune cells, fibroblasts) and competition for nutrients that favor tumor cell growth at the expense of recruited leukocytes; Renal carcinoma, soft tissue sarcoma, liver cancer, and pancreatic cancer.

Georgios Simos, Professor of Biochemistry, School of Medicine, University of Thessaly, Larissa, Greece. Research interests: The cellular response to hypoxia, focusing on the regulation of Hypoxia-Inducible factors (HIFs) and their role in metabolism and cancer progression.

Pablo Wappner, Professor of Cell and Developmental Biology, Leloir Institute and School of Sciences, University of Buenos Aires, Argentina. Research interests: Screen for new HIF regulators; Adaptation to hypoxia and activation of autophagy; miRNAs involved in HIF regulation; HIF translational regulation.

Moira Whyte, Vice Principal and Head of the College of Medicine and Veterinary Medicine, Sir John Crofton Professor of Respiratory Medicine, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK. Research interests: Respiratory Medicine; Inflammation; Neutrophil biology.

Lei Xi, Associate Professor of Medicine, Pauley Heart Center, Department of Internal Medicine, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA. Research interests: Intermittent Hypoxia, Cardiovascular Pharmacology, Cardioprotection, Nitric Oxide, Biomarkers, Ischemia-Reperfusion Injury, HIF-1, Diabetes and Metabolic Syndrome, Sports Medicine.