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Intrauterine hypoxia: clinical consequences and therapeutic perspectives

Authors Thompson L, Crimmins S, Telugu B, Turan S

Received 30 April 2015

Accepted for publication 21 June 2015

Published 15 September 2015 Volume 2015:5 Pages 79—89

DOI https://doi.org/10.2147/RRN.S57990

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Robert Schelonka


Loren P Thompson,1 Sarah Crimmins,1 Bhanu P Telugu,2 Shifa Turan1

1Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA; 2Department of Animal Sciences, University of Maryland, College Park, MD, USA

Abstract: Intrauterine hypoxia is a significant clinical challenge in obstetrics that affects both the pregnant mother and fetus. Intrauterine hypoxia can occur in pregnant women living at high altitude and/or with cardiovascular disease. In addition, placental hypoxia can be generated by altered placental development and spiral artery remodeling leading to placental insufficiency and dysfunction. Both conditions can impact normal maternal cardiovascular homeostasis leading to preeclampsia and/or impair transfer of O2/nutrient supply resulting in fetal growth restriction. This review discusses the mechanisms underlying altered placental vessel remodeling, maternal and fetal consequences, patient management, and potential future therapies for improving these conditions.

Keywords: fetal growth restriction, oxidative stress, extravillous trophoblast invasion, Doppler ultrasound, pulsatility index, preeclampsia
 

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