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Interaction between paliperidone extended release and TS-1®, an oral anticancer drug containing a 5-fluorouracil derivative, in a schizophrenic patient

Authors Yasui-Furukori N, Hashimoto K, Kubo K, Tomita T, Nakagami T

Received 17 December 2012

Accepted for publication 3 January 2013

Published 3 March 2013 Volume 2013:9 Pages 317—320

DOI https://doi.org/10.2147/NDT.S41738

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Norio Yasui-Furukori, Kojiro Hashimoto, Kazutoshi Kubo, Tetsu Tomita

Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan

Abstract: Until now there has been no information available on drug interaction between paliperidone and TS-1®, an oral anticancer drug containing a 5-fluorouracil derivative. The patient in the case presented here was a 39-year-old man with a 15-year history of schizophrenia. The patient's usual treatment of 2 mg/day of risperidone was changed to 3 mg/day of paliperidone extended release. He experienced worsening psychotic symptoms after switching from risperidone to paliperidone while he was also receiving TS-1. Retrospective analyses showed plasma concentration of paliperidone was consistently lower during the treatment with TS-1 than without TS-1. This case suggests there is drug interaction between paliperidone extended-release tablets and TS-1.

Keywords:
schizophrenia, antipsychotic, OROS, diarrhea, Positive and Negative Syndrome Scale

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