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Influence of hypothyroidism on renal function of lithium-treated patients

Authors Lozano R, Marín R, Santacruz M

Received 26 November 2015

Accepted for publication 28 November 2015

Published 23 December 2015 Volume 2016:12 Pages 25—27

DOI https://doi.org/10.2147/NDT.S101328

Checked for plagiarism Yes

Editor who approved publication: Dr Roger Pinder


Roberto Lozano, Reyes Marín, María-Jesús Santacruz

Pharmacy Department, Aragones Health Service, Zaragoza, Spain

Several studies have shown that lithium maintenance treatment for bipolar disorder (BD) is associated with chronic kidney disease (CKD).1–3 Three recent and large controlled studies concluded that lithium treatment, within recommended serum levels, may increase the risk of induced end-stage renal disease by twofold1,2 or, alternatively, CKD is associated with BD independent of drug treatment.3 Moreover, review of the safety data on lithium shows a 0–5 mL/min reduction in glomerular filtration rate and a clear reduction in urinary concentrating capacity, during an observation period of 1 year.4


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