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Inflammation in gastrointestinal disorders: prevalent socioeconomic factors

Authors Ribaldone DG, Pellicano R, Actis GC

Received 1 April 2019

Accepted for publication 24 June 2019

Published 19 July 2019 Volume 2019:12 Pages 321—329

DOI https://doi.org/10.2147/CEG.S210844

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Professor Andreas M. Kaiser


Video abstract presented by Davide Giuseppe Ribaldone.

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Davide Giuseppe Ribaldone,1 Rinaldo Pellicano,2 Giovanni Clemente Actis3

1Department of Surgical Sciences, University of Turin, Turin, Italy; 2Unit of Gastroenterology, Molinette-San Giovanni Antica Sede (SGAS) Hospital, Turin, Italy; 3The Medical Center Practice Office, Turin, Italy

Abstract: Western populations harbor a chronic inflammation pattern that lacks organ cardinal signs (edema, increased temperature, pain, and impaired function), releases increased levels of C-reactive protein, and often runs a creeping clinical course with generalized debilitating disease superimposed on system-specific involvement, mostly including nervous tissue (multiple sclerosis, Parkinson’s syndromes), joints (arthritis), and skin (psoriasis). A finalistic interpretation may apply to the consideration of the gut as the source of inflammation. In fact, these kind of local events as well as the remote manifestations named above, could be conditioned by the microbiome, the huge cell population indwelling the gut which is under growing scrutiny. The role of the gut as a barrier organ justifies lingering submucosal inflammation as a patrolling activity to maintain bodily integrity; the microbiome, launching inflammogenic signals in response to abrupt diet changes, confers to gut inflammation a socioeconomic vector calling for hitherto unrecognized multi-disciplinary interventions.

Keywords: colorectal cancer, inflammation, inflammatory bowel disease, irritable bowel syndrome, microbiome

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