Induced cytokine network during experimental African trypanosomiasis
Karina Pires de Sousa, Jorge M Atouguia, Marcelo Sousa Silva
Unidade de Ensino e Investigação de Clínica Tropical, Centro de Malária e Outras Doenças Tropicais (CMDT), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
Abstract: African trypanosomiasis (AT) is caused by extracellular hemoflagellates of the genus Trypanosoma and develops into a fatal disease for man and animals. The immune response and pathogenesis associated with the illness are complex and still poorly understood. However, they seem to be characterized by extensive changes in lymphoid tissues of the infected host, involving a complex network of interactions between cells and their products, which are controlled by specific parasite molecules. Various studies suggest that cytokine responses influence the outcome of AT; however, the precise role of individual cytokines remains unclear and may depend on the animal model and the parasite strain. This review focuses on how the parasite manipulates the immunoregulatory mechanisms in the generation of host cytokine response and their relationship with macrophages activation in the experimental model of the African sleeping sickness.
Keywords: Trypanosoma brucei, sleeping sickness, T helper cells
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.