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Imported melioidosis in Japan: a review of cases

Authors Hadano Y

Received 20 October 2017

Accepted for publication 22 December 2017

Published 24 January 2018 Volume 2018:11 Pages 163—168

DOI https://doi.org/10.2147/IDR.S154696

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Joachim Wink

Yoshiro Hadano

Department of Infectious Diseases, St. Mary’s Hospital, Kurume, Fukuoka, Japan

Abstract: Fourteen cases of reported melioidosis in Japan were reviewed. The mean age was 52.4 years (33–69 years), and all patients were male. All of the presumed exposures originated in Southeast Asia. The most common underlying disease was diabetes mellitus, including those patients with impaired glucose tolerance (n=8). As for mode of onset, 13 patients had acute infections and one had chronic infection. Of these 14 patients, the most common infection site on admission was lung (n=8), followed by bone (n=5), skin (n=4), gastrointestinal abscess formation (n=3), urinary tract (n=3), aorta (n=2), mediastinal lymph node swelling (n=1), and central nervous system (n=1). Bacteremia was observed in nine patients, and Burkholderia pseudomallei isolates were mostly susceptible to ceftazidime and carbapenem. Overall mortality was 14.3%. Melioidosis is a rare infection in Japan, with all known cases to date having been imported from Southeast Asia. Diabetes was a common risk factor.

Keywords: melioidosis, Burkholderia pseudomallei, Japan, Southeast Asia
 

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