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Importance of acute renal failure with ibuprofen

Authors Tufan F

Received 23 March 2014

Accepted for publication 27 March 2014

Published 5 May 2014 Volume 2014:9 Pages 763—764

DOI https://doi.org/10.2147/CIA.S64674


Fatih Tufan

Sevket Yilmaz Training and Research Hospital, Geriatrics Unit, Yildirim, Bursa, Turkey
Kuptniratsaikul et al report the efficacy of Curcuma domestica extracts in the treatment of knee osteoarthritis.1 One of my concerns about this well designed study is lack of one important adverse event assessment. One of the most important adverse effects of ibuprofen, which is a non-selective non-steroid anti-inflammatory drug, is acute renal failure.2 Although one of the exclusion criteria in this study is renal failure, especially in the elderly population, it is crucial to follow up kidney functions under non-steroid anti-inflammatory treatment.
View original paper by Kuptniratsaikul and colleagues

Dear editor

Kuptniratsaikul et al report the efficacy of Curcuma domestica extracts in the treatment of knee osteoarthritis.1 One of my concerns about this well designed study is lack of one important adverse event assessment. One of the most important adverse effects of ibuprofen, which is a non-selective non-steroid anti-inflammatory drug, is acute renal failure.2 Although one of the exclusion criteria in this study is renal failure, especially in the elderly population, it is crucial to follow up kidney functions under non-steroid anti-inflammatory treatment.

Disclosure

The author has no conflicts of interest to disclose.


References

1.

Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451–458.

2.

Risser A, Donovan D, Heintzman J, Page T. NSAID prescribing precautions. Am Fam Physician. 2009;80(12):1371–1378.

Author’s reply

Vilai Kuptniratsaikul

Department of Rehabilitation Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Correspondence: Vilai Kuptniratsaikul, Department of Rehabilitation Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd, Bangkok 10700, Thailand Tel +66 2 419 7508 Fax +66 2411 4813 Email vilai.kup@mahidol.ac.th


Dear editor

We thank Professor Tufan very much for the valuable comment regarding the study entitled “Efficacy and safety of Curcuma domestica extracts compared to ibuprofen in patients with knee osteoarthritis: a multicenter study”, published in Clinical Interventions in Aging.1 His concern is about acute renal failure in aging patients receiving non-steroidal anti-inflammatory drugs, especially ibuprofen. We were also concerned about this, therefore one of our exclusion criteria was abnormal renal function.1 In addition, every patient had blood chemistry tests (complete blood count, liver function [serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase] and renal function [blood urea nitrogen, creatinine]) at week 0 and week 4 (at the end of the study). The results of the blood chemistry tests of both groups were compared before and after the study (presented in Table 3 in our original paper).1 There were no differences between blood urea nitrogen and creatinine within each group. Additionally, no one developed acute renal failure during the study.

Disclosure

The author has no conflicts of interest to disclose.


Reference

1.

Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451–458.

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