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Immune Response-Related Genes – STAT4, IL8RA and CCR7 Polymorphisms in Lung Cancer: A Case–Control Study in China

Authors Ma Y, Zhou Y, Zhang H, Su X

Received 14 July 2020

Accepted for publication 22 September 2020

Published 21 October 2020 Volume 2020:13 Pages 511—519


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Martin Bluth

Yunfan Ma, Yinxi Zhou, Huixin Zhang, Xiaoan Su

Department of Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, People’s Republic of China

Correspondence: Yunfan Ma
Department of Thoracic Surgery, General Hospital of Ningxia Medical University, #804 Shengli South Road, Xingqing Region, Yinchuan, Ningxia 750004, People’s Republic of China
Tel/Fax +86 951-6743244

Purpose: This study aimed to evaluate the associations between immune response-related genes – STAT4, IL8RA and CCR7 polymorphisms and risk of lung cancer.
Methods: Seven polymorphisms of STAT4, IL8RA and CCR7 were genotyped in 350 cases and 350 controls using a MassARRAY platform.
Results: The STAT4 rs1400656-G and rs7574865-T alleles may decrease the susceptibility to lung cancer (prs1400656= 0.020; prs7574865= 0.014); while IL8RA rs1008562-C and CCR7 rs3136685-T alleles may increase the risk of disease (prs1008562< 0.001; prs3136685= 0.018). The STAT4 rs1400656-GA and rs7574865-GT genotypes were determined as protective genotypes against lung cancer risk (prs1400656= 0.048; prs7574865= 0.042). However, IL8RA rs1008562-CG/GG and CCR7 rs3136685-TT genotypes were significantly associated with an elevated risk of disease (prs1008562< 0.0001; prs3136685= 0.020). Genetic model analysis revealed that STAT4 rs1400656 and rs7574865 were relate to a declining risk of disease under dominant and log-additive models (rs1400656: p dominant = 0.014, p log-additive= 0.016; rs7574865: p dominant = 0.013, p log-additive= 0.013). In contrast, IL8RA rs1008562 exhibited a strong correlation with an elevated risk of lung cancer under all three models (p dominant < 0.0001, p recessive = 0.011, p log-additive< 0.0001). Moreover, CCR7 rs3136685 was correlated with an increased risk of disease under recessive and log-additive models (p recessive = 0.007, p log-additive= 0.019); and CCR7 rs17708087 was also identified as a risk factor in the dominant model (p = 0.038).
Conclusion: These results widen the scope of knowledge about the association between STAT4, IL8RA and CCR7 polymorphisms and risk of lung cancer.

Keywords: lung cancer, signal transducers and activators of transcription 4, STAT4, interleukin 8-receptor alpha, IL8RA, Chemokine (C-C motif) receptor 7, CCR7, single nucleotide polymorphisms, SNPs

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