Higher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based study
Received 21 November 2018
Accepted for publication 10 May 2019
Published 24 June 2019 Volume 2019:12 Pages 901—911
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 3
Editor who approved publication: Dr Steven F. Abcouwer
Xiaotong Dai,1 Ying Yang,2 Guan-Liang Cheng,2 Jia Jia,2 Fang-Fang Fan,2 Jian-Ping Li,2 Yong Huo,2 Zhike Liu,1 Dafang Chen,1 Yan Zhang2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People’s Republic of China; 2Department of Cardiology, Peking University First Hospital, Beijing, People’s Republic of China
Background: Increased arterial stiffness measured by brachial-ankle pulse wave velocity is associated with cardiovascular disease. However, the rates at which brachial-ankle pulse wave velocity and blood glucose accelerate within individuals who differ in blood pressure levels are largely unknown.
Methods: This study was based on the baseline data of a Chinese community-based atherosclerosis cohort which included 7402 individuals. Using generalized linear regression models, the relationship between blood glucose levels and brachial-ankle pulse wave velocity, and the relationship between blood pressure levels and brachial-ankle pulse wave velocity were examined.
Results: A marked interaction between hypertensive state and diabetic state was seen for brachial-ankle pulse wave velocity (P for interaction <0.001). The adjusted coefficient for subjects stratified by hypertensive groups and diabetic states showed that the highest brachial-ankle pulse wave velocity risk subjects were those who had both diabetes and hypertension (B=403.24; 95% CI: 372.43–434.05; P<0.001).
Conclusions: The participants with increased arterial stiffness demonstrate a high prevalence of higher blood pressure. When high blood glucose levels co-occur with high blood pressure levels, there is a remarkable increase in arterial stiffness.
Keywords: communities, diabetes, hypertension
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