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High density lipoprotein cholesterol: an evolving target of therapy in the management of cardiovascular disease

Authors Kapur NK, Ashen D, Blumenthal RS

Published 8 February 2008 Volume 2008:4(1) Pages 39—57


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Navin K Kapur, Dominique Ashen, Roger S Blumenthal

Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Abstract: Since the pioneering work of John Gofman in the 1950s, our understanding of high density lipoprotein cholesterol (HDL-C) and its relationship to coronary heart disease (CHD) has grown substantially. Numerous clinical trials since the Framingham Study in 1977 have demonstrated an inverse relationship between HDL-C and one’s risk of developing CHD. Over the past two decades, preclinical research has gained further insight into the nature of HDL-C metabolism, specifically regarding the ability of HDL-C to promote reverse cholesterol transport (RCT). Recent attempts to harness HDL’s ability to enhance RCT have revealed the complexity of HDL-C metabolism. This review provides a detailed update on HDL-C as an evolving therapeutic target in the management of cardiovascular disease.

Keywords: high density lipoprotein cholesterol (HDL-C), coronary, atherosclerosis, reverse cholesterol transport

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