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Hepatocellular carcinoma in elderly patients: challenges and solutions

Authors Brunot A, Le Sourd S, Pracht M, Edeline J

Received 28 November 2015

Accepted for publication 12 February 2016

Published 17 June 2016 Volume 2016:3 Pages 9—18

DOI https://doi.org/10.2147/JHC.S101448

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Dong Chen

Peer reviewer comments 3

Editor who approved publication: Professor Ahmed O Kaseb

Angélique Brunot, Samuel Le Sourd, Marc Pracht, Julien Edeline

Department of Medical Oncology, Centre Eugene Marquis, Rennes, France

Abstract: Hepatocellular carcinoma (HCC) is the second most common cause of death by cancer in the world. Due to the delayed HCC development in hepatitis C carriers and nonalcoholic fatty liver disease, the incidence of HCC in the elderly is increasing and is becoming a global health issue. Elderly patients with HCC should be assessed through proper oncologic approach, namely, screening tools for frailty (Geriatric-8 or Vulnerable Elders Survey-13) and comprehensive geriatric assessment. This review of the literature supports the same treatment options for elderly patients as for younger patients, in elderly patients selected as fit following proper oncogeriatric assessment. Unfit patients should be managed through a multidisciplinary team involving both oncological and geriatrician professionals. Specific studies and recommendations for HCC in the elderly should be encouraged.

Keywords: liver cancer, treatment, surgery, geriatric evaluation, sorafenib

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