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Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats

Authors Qin Q, Lin N, Huang H, Zhang X, Cao X, Wang Y, Li P

Received 16 March 2019

Accepted for publication 22 May 2019

Published 10 July 2019 Volume 2019:12 Pages 1091—1103

DOI https://doi.org/10.2147/DMSO.S208989

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 3

Editor who approved publication: Dr Antonio Brunetti


Qiaoji Qin, Nan Lin, Huan Huang, Xuezhi Zhang, Xuelei Cao, Yongbin Wang, Peng Li

Emergency Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, People’s Republic of China

Background and purpose: Ginsenoside Rg1 (GS Rg1), as an important active substance of Panax ginseng, has been proven to have elaborate cardioprotective effects. The purpose of this study was to detect that GS Rg1 attenuates cardiac oxidative stress and inflammation in streptozotocin (STZ)-induced diabetic rats (DM).
Methods: Cardiac function was assessed by heart rate and blood pressure. Markers relevant to myocardial oxidative stress and antioxidant capacity, and inflammatory reaction factors were detected. The mRNA and protein expression were detected by RT-qPCR and Western blot, respectively.
Results: GS Rg1 treatment significantly reduced the symptoms of cardiac hypertrophy and hypertension, and also decreased oxidative stress, inflammation response, NF-κB expression and NLRP3 inflammasome expression. GS Rg1 enhanced mitochondrial biogenesis by increasing PGC-1α, complex III and complex Ⅳ expression. GS Rg1 treatment significantly increased the expression of AMPK, Nrf2 and HO-1 in cardiac tissues.
Conclusion: GS Rg1 exhibited protective effect against STZ-induced cardiac dysfunction, which is potentially associated with AMPK/Nrf2/HO-1 signal pathway.

Keywords: Ginsenoside Rg1, oxidative stress, inflammation, AMPK, Nrf, HO-1

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