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Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study

Authors Molina-Guzman G, González-Castro TB, Hernández-Díaz Y, Tovilla-Zárate CA, Juárez-Rojop IE, Guzmán-Priego CG, Genis A, Pool García S, López-Narvaez ML, Rodriguez-Perez JM

Received 10 September 2016

Accepted for publication 25 October 2016

Published 22 February 2017 Volume 2017:13 Pages 559—566

DOI https://doi.org/10.2147/NDT.S122024

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Gabriel Molina-Guzman,1 Thelma Beatriz González-Castro,2 Yazmín Hernández Díaz,2 Carlos Alfonso Tovilla-Zárate,3 Isela E Juárez-Rojop,3 Crystell Guadalupe Guzmán-Priego,3 Alma Genis,4 Sherezada Pool García,5 María Lilia López-Narvaez,6 José Manuel Rodriguez-Perez7

1División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, 2División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, 3División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México; 4Instituto Nacional de Medicina Genómica (INMEGEN), Servicios de Atención Psiquiátrica (SAP), Secretaría de Salud, Ciudad de México, México; 5Hospital General de Comalcalco, Secretaria de Salud, Comalcalco, Tabasco, México; 6Hospital General de Yajalón, Secretaría de Salud, Yajalón, Chiapas, México; 7Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México

Background: The aim of this case–control study was to explore the association by gender between the HTR2C gene variants and suicidal behavior in a Mexican population.
Subjects and methods: A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype.
Results: In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts. The C allele of the single-nucleotide polymorphism (SNP) rs4272555 was associated with a decreased risk of suicide attempt (P=0.01, odds ratio =0.26, 95% confidence interval: 0.09–0.79), whereas the G allele of the SNP rs2428707 was associated with an increased risk of suicide attempt (P=0.01, odds ratio =3.68, 95% confidence interval: 1.24–10.90). No significant association was observed between the other polymorphisms studied (rs547536, rs2192372, rs6318) or haplotypes with suicide attempts.
Conclusion:
These findings suggest a possible risk factor of the HTR2C gene in the pathology of suicidal behavior in Mexican population. More studies are necessary to confirm this association.

Keywords:
suicide, serotonin receptor, HTR2C gene, Mexican population, polymorphism

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