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Gamma Knife Radiosurgery For Brain Vascular Malformations: Current Evidence And Future Tasks

Authors Hasegawa H, Yamamoto M , Shin M, Barfod BE

Received 6 August 2019

Accepted for publication 22 October 2019

Published 18 November 2019 Volume 2019:15 Pages 1351—1367


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh

Hirotaka Hasegawa,1 Masaaki Yamamoto,2 Masahiro Shin,1 Bierta E Barfod2

1Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan; 2Katsuta Hospital Mito Gamma House, Hitachinaka, Ibaraki, Japan

Correspondence: Masaaki Yamamoto
Katsuta Hospital Mito GammaHouse, 5125-2 Nakane, Hitachi-Naka, Ibaraki 312-0011, Japan
Tel +81-29-271-0011
Fax +81-29-274-1475
Email [email protected]

Abstract: Gamma Knife radiosurgery (GKRS) has long been used for treating brain vascular malformations, including arteriovenous malformations (AVMs), dural arteriovenous fistulas (DAVFs), and cavernous malformations (CMs). Herein, current evidence and controversies regarding the role of stereotactic radiosurgery for vascular malformations are described. 1) It has already been established that GKRS achieves 70–85% obliteration rates after a 3–5-year latency period for small to medium-sized AVMs. However, late radiation-induced adverse events (RAEs) including cyst formation, encapsulated hematoma, and tumorigenesis have recently been recognized, and the associated risks, clinical courses, and outcomes are under investigation. SRS-based therapeutic strategies for relatively large AVMs, including staged GKRS and a combination of GKRS and embolization, continue to be developed, though their advantages and disadvantages warrant further investigation. The role of GKRS in managing unruptured AVMs remains controversial since a prospective trial showed no benefit of treatment, necessitating further consideration of this issue. 2) Regarding DAVFs, GKRS achieves 41–90% obliteration rates at the second post-GKRS year with a hemorrhage rate below 5%. Debate continues as to whether GKRS might serve as a first-line solo therapeutic modality given its latency period. Although the post-GKRS outcomes are thought to differ among lesion locations, further outcome analyses regarding DAVF locations are required. 3) GKRS is generally accepted as an alternative for small or medium-sized CMs in which surgery is considered to be too risky. The reported hemorrhage rates ranged from 0.5–5% after GKRS. Higher dose treatments (>15 Gy) were performed during the learning curve, while, with the current standard treatment, a dose range of 12–15 Gy is generally selected, and has resulted in acceptable complication rates (< 5%). Nevertheless, further elucidation of long-term outcomes is essential.

Keywords: arteriovenous malformation, cavernous malformation, dural arteriovenous fistula, gamma knife radiosurgery, stereotactic radiosurgery


Based on the concept of stereotactic radiosurgery that was first introduced in 1951, the gamma unit was designed by Lars Leksell using multiple 60Co sources focused at a fixed center.1,2 Characterized by its single-session focused irradiation with high accuracy and sharp dose fall-off,3,4 gamma knife radiosurgery (GKRS) was first introduced clinically in 1968 and has since been used to treat more than one million patients worldwide with a variety of cerebral/cranial conditions.2,57 Arteriovenous malformation (AVM), dural arteriovenous fistula (DAVF), and cavernous malformation (CM) are the main GKRS targets; all are categorized as brain vascular malformations and are essentially caused by arteriovenous shunting, though their conditions and responses to GKRS are entirely different. Numerous studies, including systematic reviews and multicenter retrospective analyses, have examined radiosurgical outcomes of these disorders and the efficacy of GKRS has been well established. Nevertheless, several problems remain that must be addressed. Herein, we summarize current evidence supporting the use of GKRS for such brain vascular malformations and discuss persisting controversies.

GKRS Procedures For Vascular Malformations

Using local anesthesia with or without sedation, the patient’s head is fixed in a Leksell Coordinate Frame G (Elekta AB, Stockholm, Sweden). The patient is then sent to a radiographic suite to undergo stereotactic imaging studies, including magnetic resonance imaging (MRI), computed tomography (CT), and digital subtraction angiography (DSA). These imaging studies are performed with fitting of an appropriate indicator on the frame, which imposes fiducials on images of the patient. The acquired image dataset is then sent to GammaPlan (Elekta AB), a radiosurgical planning software program. In creating the radiosurgical plan, an appropriate prescription dose is aimed at the target’s margin usually using a 50–60% isodose gradient while a 70–90% isodose gradient occasionally is used in patients with a relatively small target. A margin, the setting of which is usually recommended in linac-based radiosurgery, is not required.

GKRS For Arteriovenous Malformation

Current Evidence

Brain AVM is the most common brain vascular malformation with a prevalence of just under 10 per 100,000.810 The hemorrhage risk is reported to be approximately 3%/year. Once a hemorrhage occurs, the possibilities of neurologic deficits and death are < 50% and < 10%, respectively.8,11,12 Therefore, the treatment goal is to eliminate the risk of hemorrhage, which can be achieved by isolating the nidus from the circulation. GKRS is considered to be a main therapeutic modality and is often applied to small to medium-sized AVMs.8,1315

Generally, nidus obliteration can be achieved in 70–85% of patients after a 3–5 year latency period.1522 Though DSA is still the gold standard method for confirming nidus obliteration, there is a recent tendency to avoid DSA due to its invasiveness. MRI is generally regarded as an acceptable alternative, exhibiting 77–85% sensitivity and 89–95% specificity.23,24 Radiosurgical dose and AVM size are the factors most strongly influencing nidus obliteration.1518,20,21,2545 The Pittsburgh radiosurgical AVM score17 with its modification41 and the Virginia radiosurgical AVM scale25 are two major scoring systems which aid neurosurgeons in predicting post-radiosurgical outcomes. As to disadvantages of GKRS, approximately 30% of patients suffer from perinidal T2-signal intensity change within 2 years after the procedure, but this becomes symptomatic in less than 10% and permanent in only 3%.15,4651 Post-GKRS hemorrhage is rare,5255 and the risk does not increase, remaining the same or decreasing during the latency period.52 Whether nidus obliteration means “complete” eradication of hemorrhage risk remains debatable.56 Bleeding due to recanalization of a once-obliterated nidus, albeit quite rare, has been reported.57,58

Late Radiation-Induced Adverse Events (RAEs)

Since the late 1990s, an increasing number of studies have described late RAEs, including cyst formation (CF), chronic encapsulated hematoma (CEH), and tumorigenesis.59 Radiation-induced chronic inflammation appears to play an important role in the former two conditions,60,61 suggesting that target size is strongly associated with their occurrence.6264 The other risk factors include lobar location, higher prescription dose, and history of embolization as pre-GKRS factors, the occurrence of early edema, additional irradiation, and the state of nidus obliteration as post-GKRS factors.6371 CF/CEH develops approximately 6.5–11.8 years after irradiation, and the cumulative incidences are estimated to range from 2.8–7.7% at 10 years and 7.6–12.5% at 15 years.64–,66,68 Though the optimal treatment remains a source of controversy, surgical resection is widely regarded as a standard option. However, fluid diversion, including cyst-peritoneal shunt and ommaya reservoir placement, are minimally invasive alternatives for exclusively cystic lesions.6466,68 Oral corticosteroids may help reduce the associated edema and alleviate symptoms; however, the long-term effects remain unknown.64,68 Previous studies on CF/CEH are summarized in Table 1.6264,6668,7274

Table 1 Literature Review On Late RAEs (Studies With ≥ 100 patients)

Regarding radiation-induced tumorigenesis, the majority of such lesions are malignant glioma.64,7579 Attempts have been made to calculate the radiation-induced tumorigenesis incidence, which has been roughly estimated to be less than 0.2%.64,75,76 The actual incidence, however, has yet to be determined due to the rarity of this condition.

Staged GKRS For Large AVMs

Large AVMs are challenging targets. Radiosurgical doses are generally reduced for fear of RAEs, which in turn could decrease the obliteration rate and might eventually result in a higher hemorrhage rate.80 In short, it is important to balance the therapeutic effect and risks. Accumulated evidence tells us that stand-alone GKRS for AVMs > 10 mL is controversial and that staged GKRS is an alternative that is frequently considered.49

There are two distinct staging methods: volume-staged GKRS (VSGKRS) and dose-staged GKRS. In VSGKRS, the entire nidus volume is divided into 2 or 3 parts, which are then irradiated independently with intervals of several months (usually 3 to 6 months).8191 On the other hand, in dose-staged GKRS, the entire nidus is irradiated repeatedly with an attenuated dose until a planned cumulative dose has been fully delivered.9194 Although no definitive conclusion has yet been reached, retrospective evidence indicates the superiority of VSGKRS.95,96

Previous studies on VSGKRS are summarized in Table 2.89,94,97,98103 The crude obliteration rates after VSGKRS range between 33% and 72%, the exception being one study reporting 13%; this broad range may be due to marked differences in nidus volumes among studies (mean, 16.8–60 mL) and the wide variety of prescription doses administered (mean, 15.5–20.8 Gy).8191,101 It seems that a dose of at least 17 Gy for each session is needed to obtain a favorable obliteration rate; if lesions are treated with ≥ 17 Gy, the obliteration rate approaches 60%.97,102 The other factors that potentially contribute to successful obliteration include larger than 20 Gy-volume coverage97 and a single drainer vessel.89 However, these results are not consistent and further research is needed. Regarding the disadvantages of VSGKRS, relatively high hemorrhage rates are the primary concern, with crude rates ranging from 4.5% up to 33%.8191,101 The occurrence of RAEs would presumably be greatly affected by the dose, volume, location, and follow-up duration, and is thus difficult to predict; however, the rate is somewhere between 0% and 40%.8190,91,101 A recent systematic review by Ilyas et al noted that the rates of obliteration, symptomatic RAEs, post-radiosurgical hemorrhage, and mortality were 41.2%, 13.7%, 19.5%, and 7.4%, respectively.95 Thus, VSGKRS is a therapeutic modality still undergoing development. Given the scarcity of cases in individual centers, a multi-center study is needed for further evaluation.

Table 2 Literature Review On Outcomes Of VSGKRS For Large AVMs (Studies With ≥ 15 patients)

Combination Of GKRS And Embolization For Large AVMs

The other option for large AVMs is a combination of neoadjuvant nidus embolization and definitive GKRS. Previous relatively large studies reporting this combination are summarized in Table 3.104113 According to several recent studies, the crude obliteration rates range from 24–72%, and 5-year obliteration rates from 31–60%.24,104118 A recent systematic review found the obliteration rate to be 41.0%, the 3-year hemorrhage rate to be 7.3%, and the RAE rate to be 3.3%119 however, these results might be misleading due to volume discrepancies and how they are defined. First, median/mean volumes in the studies included in this systematic review varied significantly; the smallest was 2.8 mL and the largest 29.5 mL. Second, most of the prior studies used residual AVM volume after embolization as a baseline value,104,105,108,109,115,120122 while others employed the pre-embolization volume,107,110114 and two studies did not describe volume in detail.116,117 Since AVM volume significantly affects radiosurgical outcomes, these discrepancies present a major obstacle to interpreting the results.

Table 3 Literature Review On Outcomes Of A Combination Of GKRS And Embolization (Studies With ≥ 25 patients)

This combination was initially deemed to be ideal because embolization can reduce the nidus volume, with minimal invasiveness, down to the level at which GKRS could be suitably applied.123,124 However, several studies later suggested that this approach might be associated with a reduction in the obliteration rate.16,109,114,119,120 This reduction might be attributable to several factors including recanalization of the embolized AVM compartments, increased difficulty in AVM demarcation for radiosurgical planning, and increased angiogenesis after embolization.36,37,123,125,126128 Nevertheless, it would be premature to abandon this combination strategy, given the volume issues discussed above. What we can learn from the relevant studies is that the obliteration rate for post-embolized AVMs might be lower than that for non-embolized AVMs with volumes similar to the residual volumes of embolized AVMs. Comparing post-embolized AVMs to non-embolized AVMs with volumes similar to the pre-embolized volume of the former would yield different results. Further studies must be designed to ascertain whether the combination therapy is beneficial for larger AVMs, by comparing the overall outcomes of both embolization and GKRS to a GKRS-based strategy without embolization, with adjustment for the pre-intervention volume between the two cohorts.

GKRS For Unruptured AVMs

Therapeutic interventions for unruptured AVMs were not regarded as being controversial until the Randomized trial of Unruptured Brain Arteriovenous malformations (ARUBA study) failed to show any advantages to treatment.129 Since then, however, a significant number of concerns about and criticisms of the ARUBA study have been raised.130 From the standpoint of GKRS, the short follow-up duration would the factor most significantly impairing the reliability of the results; a median follow-up of < 3 years is inadequate to see the benefits of GKRS that would not usually preclude the possibility of AVM rupture until obliteration is achieved after a 3–5 year latency period. Another significant issue is the lack of details regarding the treatment arms; the actual outcomes after GKRS were not documented in detail. To date, several gamma knife centers have reported comparison studies between “ARUBA-eligible patients” and the medically-managed patients in the ARUBA study, and obtained more favorable outcomes in GKRS cohorts in the late phase (Table 4).131136 Therefore, GKRS appears to be warranted for small- to medium-sized unruptured AVMs. Nevertheless, the ARUBA study was undoubtedly a turning point in the management of unruptured AVMs in the sense that it underscored the importance of being fully aware of the invasiveness of treatment and its complications when treating asymptomatic AVMs.GKRS for dural arteriovenous fistula

Table 4 Literature Review On Outcomes Of ARUBA-Eligible Patients (Studies With ≥ 100 patients)

Current Evidence

DAVFs, accounting for 10–15% of intracranial arteriovenous shunt disorders, are acquired arteriovenous shunts involving the dura mater, where arterialized dural sinuses become an obstacle to normal cerebral venous return, eventually resulting in intracranial hemorrhage and/or non-hemorrhagic neurological deficits due to venous hyperremia.137142 Presence of cortical venous drainage (CVD) and prior hemorrhage are well-known risk factors for future hemorrhage.137,138,141,143,144146 The estimated annual event rates are 7–19% for DAVFs with CVD and/or prior hemorrhage, though the rates range from 0–1.5% in the absence of these aggressive features.137,143,147149 During GKRS, the irradiation target is shunt tissues in the dura mater which can be seen on time-of-flight MRI and DSA. The prescription dose is usually between 18 and 22 Gy in most institutions. Fistula obliteration is achieved in 41–90% of treated patients after a latency period of several months to years (typically 1–3 years), with an acceptable hemorrhage rate below 5% as well as low symptomatic RAE rates ranging from 0–5%.150164 The results of recent studies with significant numbers of study participants (≥ 20) are summarized in Table 5.152155,157,161165

Table 5 Literature Review Describing Stereotactic Radiosurgery For DAVFs (Studies With ≥ 20 patients)

Unresolved Issues And Future Tasks

First, no consensus has been reached regarding factors associated with successful obliteration. Knowing those factors would be an important first step to refining appropriate case selection and radiosurgical planning, and to tailoring treatment strategies to individual patients. Several studies have attempted to identify these crucial factors, but to date cavernous sinus location and absence of CVD are the only factors suggested by more than one study.152,154,165,166 The inconsistencies among these studies indicate that further investigations are necessary to clarify the relevant issues. Unlike AVM, DAVF is likely to be treated not only with GKRS alone but also in combination with embolization and/or surgery, making it difficult to assess the reasons for failed obliteration after GKRS.

Second, the outcomes of GKRS as a solo treatment remain to be fully elucidated. Due to the latency period in which hemorrhage risk cannot be regarded as negligible, GKRS is generally considered to be an alternative method when endovascular embolization and direct surgery are not feasible or have failed, or for patients with significant medical comorbidities.144 As such, in almost all published studies focusing on GKRS for DAVFs, a significant number of patients underwent embolization before GKRS or scheduled embolization immediately after GKRS. Nevertheless, GKRS is more advantageous in terms of safety and minimal invasiveness than the other therapeutic modalities; GKRS alone is thus potentially a good therapeutic option when endeavoring to achieve a balance between efficacy and safety. Indeed, Park et al reported a 90% obliteration rate with a 0% hemorrhage rate, suggesting that GKRS might provide acceptable outcomes when used as a solo treatment.163 However, their study was based on only 20 patients.

Third, since studies have suggested that cavernous sinus location is associated with fistula obliteration, fistula location may affect radiosurgical outcomes. Taking AVMs as an example, nidus location significantly affects treatment outcomes.16,25,41,49,167 To date, however, no study has addressed this issue, probably due to relatively small patient numbers. Starke et al recently reported the first multicenter retrospective analysis of data from 114 patients, approximately half of whom had undergone prior embolization, though they did not show location-specific outcomes, a factor which should be considered in future studies.165

In conclusion, GKRS has the potential to become a first-line therapeutic option for DAVFs. However, its efficacy must be further confirmed with additional studies based on a large number of participants. Due to the scarcity of cases in a single institution, this goal might be achievable only by conducting a multi-institutional investigation with a large combined sample population. At present, a multi-institutional study is ongoing in Japan (JLGK1802, University Medical Information Network Registry No. UMIN000037211).

GKRS For Cavernous Malformation

Current Evidence

Brain CM is a low-flow and angiographically-occult vascular lesion, accounting for 10% to 15% of all brain vascular malformations.168170 A CM becomes symptomatic when it bleeds and expands or causes seizures. In general, the hemorrhage rate for those in deep locations (for brainstem, thalamus, and basal ganglia lesions, the hemorrhage rate is 3–10%/year) exceeds that for CM in lobar locations (0–12%/year), and the rate for those with prior hemorrhage (5–23%/year) is higher than that for CM without prior bleeding (0–1%/year).171177 The 5-year risk of additional hemorrhage or neurological decline for those with a prior hemorrhage is high, up to 42% if untreated, though the risk diminishes over time.178

Asymptomatic CMs are better managed conservatively since the risk of a first-ever intracranial hemorrhage is low and functional impairment from the hemorrhage would be mild; only patients with symptomatic and/or progressive lesions are regarded as good candidates for interventions.170,178180 Surgical resection is recommended for superficial lesions; whereas radiosurgery is considered for those located deep inside the brain, such as lesions in the basal ganglia, thalamus, and brainstem.169,170,179

Before the early 2000s, mainly high radiosurgical doses (≂18 Gy) were used, which contributed to a relatively high rate of RAEs.181184 Currently, low doses (≤ 15 Gy) are generally preferred, and provide a level of effectiveness similar to that of higher doses but with a lower risk profile (Table 6).181,185195

Table 6 Literature Review Of Recent Studies Describing Stereotactic Radiosurgery For CMs

The goal of GKRS is to minimize the risk of bleeding, which can be achieved within an approximately two-year latency period. The short- to mid-term outcomes up to ≂ 5 years are well-known. Recent retrospective studies have shown the post-radiosurgical hemorrhage rates to range from 3.3–15%/year within two years after GKRS and 0.8–4.7%/year thereafter (Table 2), a remarkable reduction compared to the pre-radiosurgical hemorrhage rates ranging from 20–40%.181,185195 The histopathological responses following GKRS are not yet fully understood. Based on the best of currently available evidence, GKRS induces collagen formation, vessel wall-thickening, thrombus formation, and hyalinization in CM sinusoids, which then develop over the course of several months to a few years.196198 These changes can be accompanied by some areas of neovascularization, which might be responsible for post-radiosurgical hemorrhage and raise the concerns discussed below.198

Unresolved Issues And Future Tasks

First, the optimal radiosurgical dose for CMs has not as yet been standardized, with the mean prescription doses ranging from 11 and 16 Gy (Table 6).181,185195 Reflecting this, the dose-volume response also has not been clarified. These two issues are rather challenging because, unlike AVMs, there would be little visible or apparent change allowing clinicians to determine whether GKRS is effective. The only measurable therapeutic outcome is the hemorrhage rate.

Second, long-term efficacy has not been adequately examined. It seems that GKRS cannot completely eliminate the hemorrhage risk. To date, three studies have attempted to address this issue,186,194,195 of which the one with the longest follow-up (mean, 9.3 years)186 showed a post-radiosurgical hemorrhage rate for the first 5 years of 1.5–3.3%/year, apparently much better than the natural history documented in a prospective study178 (the rate of hemorrhage or neurological event; 20%/year during the first year, 12–13%/year during the second to third years, and 5%/year during the fourth to fifth years), while a mild increase up to 4.6%/year was noted after 5 years. These data underscore the importance of conducting further research, with larger patient populations and longer follow-up periods, to define the long-term efficacy of GKS.


GKRS is highly effective for small to medium-sized AVMs. VSGKRS and a combination of embolization and GKRS are currently being developed as therapeutic options for larger AVMs. These approaches require additional evaluation with larger sample sizes and longer follow-up periods. GKRS for DAVF is feasible as a minimally invasive option but further multicenter studies are needed to both clarify efficacy as a solo treatment modality and confirm factors required for successful obliteration, as well as to examine location-specific outcomes. GKRS for CMs is also feasible for obtaining short- to mid-term prevention of additional hemorrhage. Further long-term follow-up studies are necessary to identify the long-term benefits of GKRS and optimize radiosurgical doses.


The authors report no conflicts of interest in this work.


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