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Fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment

Authors Hu JB, Lai JB, Zheng HZ, Hu SH, Xu Y

Received 14 June 2017

Accepted for publication 9 August 2017

Published 24 August 2017 Volume 2017:13 Pages 2251—2254

DOI https://doi.org/10.2147/NDT.S143965

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Jianbo Hu,1,2,* Jianbo Lai,1,2,* Hanzhi Zheng,3 Shaohua Hu,1,2 Yi Xu1,2

1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou, China; 3Department of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, China

*These authors contributed equally to this work


Abstract: Depressed patients often complain of sleep disturbance. Routine antidepressive strategies sometimes fail to deal with this intractable issue. Indeed, the supplementation of sleep promoting antidepressants (eg, trazodone, mirtazapine, and agomelatine) is prevalent in clinical practice. However, the combination of different antidepressants may increase the affective lability. Herein, we document a patient with unipolar depression who was compliant with sertraline treatment and who dramatically switched to mania after adding trazodone as a sleeping aid. This case extended our understanding of the potential manic-switching risk when trazodone is used to promote sleep.

Keywords: trazodone, sertraline, depression, mania

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