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Factors Associated with the Development of Postnatal Depression After Cesarean Delivery: A Prospective Study

Authors Chan CLJ, Tan CW, Chan JJI, Sultana R, Chua TE, Chen HY, Sia ATH, Sng BL

Received 11 December 2019

Accepted for publication 3 March 2020

Published 12 March 2020 Volume 2020:16 Pages 715—727


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Yuping Ning

Carolyn Li-Jen Chan,1,* Chin Wen Tan,1,2,* Jason Ju In Chan,1 Rehena Sultana,3 Tze-Ern Chua,4,5 Helen Yu Chen,4,5 Alex Tiong Heng Sia,1,2 Ban Leong Sng1,2

1Department of Women’s Anesthesia, KK Women’s and Children’s Hospital, Singapore; 2Anesthesiology and Perioperative Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore; 3Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore; 4Department of Psychological Medicine, KK Women’s and Children’s Hospital, Singapore; 5Pediatrics Academic Clinical Program, Duke-NUS Medical School, Singapore

*These authors contributed equally to this work

Correspondence: Ban Leong Sng Tel +65 6394 1081
Fax +65 62912661

Purpose: Pre-operative association factors (pain and psychological vulnerability) could significantly contribute to post-Cesarean pain; however, limited information is available on the development of postnatal depression (PND). We aimed to investigate the development of PND and its association with pain vulnerability and psychological vulnerability factors.
Patients and Methods: Women undergoing Cesarean delivery under spinal anesthesia were given pre-operative questionnaires, psychological and pain assessments including pain on local anesthetic injection during spinal anesthesia and mechanical temporal summation. Post-operative assessments were administered at 6 to 10 weeks post-Cesarean delivery via follow-up survey to assess post-Cesarean psychological and pain outcomes.
Results: PND occurred in 21.1% (43 of 205) of patients who underwent elective Cesarean delivery. An increased pre-operative pain score with movement (Odds ratio (OR) 1.65, 95% CI 1.12– 2.44, p = 0.0110), anxiety about upcoming surgery (OR 1.02, 95% CI 1.00– 1.04, p = 0.0429), higher pre-operative Hospital Anxiety and Depression Scale (HADS) subscale on anxiety (OR 1.25, 95% CI 1.07– 1.45, p = 0.0041) and higher pre-operative central sensitization inventory (CSI) scores (OR 1.05, 95% CI 1.01– 1.09, p = 0.0156) were independently associated with an increased risk of PND. Anticipated pain medication needs were associated with reduced risk of PND (OR 0.48, 95% CI 0.29– 0.79, p = 0.0038) (Receiver operating characteristic (ROC) = 0.8177).
Conclusion: Higher pre-operative anxiety, pain score, central sensitization and lower anticipated pain medication needs were associated with increased risks of PND. Further work using larger sample size will be needed to validate the model in predicting PND development after Cesarean delivery.

Keywords: pain, central sensitization, anxiety, anticipated pain medication needs

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