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Factors Associated with Compliance with the Treatment Protocol and Mortality in Adults with Hemophilia

Authors Soares BMD , Simeoni LA , de Almeida KJQ , de Souza JL, Imoto AM, Braverman MS , Bezerra LB , Ribeiro AJT , Costa AM , Amorim FF 

Received 29 August 2020

Accepted for publication 16 October 2020

Published 20 November 2020 Volume 2020:14 Pages 2279—2285

DOI https://doi.org/10.2147/PPA.S279401

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Johnny Chen



Beatriz Mac Dowell Soares,1,2 Luiz Alberto Simeoni,2 Karlo Jozefo Quadros de Almeida,1 Jaqueline Lima de Souza,1 Aline Mizusaki Imoto,1,3 Melina Swain Braverman,3 Lucas Barbosa Bezerra,1 Alexandre Jorge Teixeira Ribeiro,1,3 Ana Maria Costa,1 Fábio Ferreira Amorim1,2

1School of Medicine, Higher Education School of Health Sciences (ESCS), Faculdade de Ciências de Saúde Campos Univ, Brasília, Federal District, Brazil; 2Faculty of Health Sciences, University of Brasilia (UnB) – Brasília, Faculdade de Ciências de Saúde Campos Univ, Brasília, Federal District, Brazil; 3Brasília Hemocentro Foundation (FHB), SMHN Conjunto A Bloco 3, Brasília, Federal District, Brazil

Correspondence: Beatriz Mac Dowell Soares
School of Medicine, Escola Superior de Ciências da Saúde (ESCS), SMHN Conjunto A Bloco 01 Edifício Fepecs – Asa Norte, Brasília – DF, Brasília CEP: 70710-907, Federal District, Brazil
, Tel +55 61999836446
Email [email protected]

Objective: Hemophilia is associated with a high prevalence of disabilities and mortality. This finding can be influenced by patient compliance with the treatment protocol. This study aims to identify compliance with a treatment protocol in adult patients with hemophilia and to evaluate the factors associated with and the impact on mortality of noncompliance with a hemophilia treatment protocol.
Methods: This was a cross-sectional study that was performed between June 2015 and May 2016, followed by a cohort to evaluate mortality until July 2019 that included all adult patients with hemophilia registered in the Federal District, Brazil.
Results: Among 138 patients enrolled in the study, 35 patients were compliant with all items of the treatment protocol (25.4%). Regarding each item, compliance with the medical consultations was 71.0% (98/138); the clotting factor regimen was 65.9% (91/138); and the serological tests were 51.4% (71/138). The mortality was 7.2% (10/138). Noncompliance with any aspect of the protocol was associated with mortality: medical consultations (p< 0.001), clotting factor regimen (p=0.013), and serological tests (p=0.006). All deaths occurred in those who did not comply with the protocol, and the majority were due to bleeding. Patients who were noncompliant with all protocol items showed the highest mortality (50.0%, 5/10). Treatment at the hemophilia treatment center (OR: 2.388; 95% CI: 1.052– 5.418, p=0.037) was positively and independently associated with compliance with the protocol in multivariate analysis.
Conclusion: Noncompliance with the treatment protocol was high. Treatment at a hemophilia treatment center was positively and independently associated with compliance with the protocol, which reinforces the importance of comprehensive care by a multidisciplinary team.

Keywords: hemophilia A, hemophilia B, patient compliance, medication adherence, treatment adherence and compliance, clinical protocols

Introduction

Hemophilia is an inherited X-linked bleeding disorder characterized by factor VIII (hemophilia A) or factor IX deficiency (hemophilia B). The goal of hemophilia treatment is to reduce bleeding episodes to prevent squeal due to hemorrhagic events and mortality risk, and treatment is mainly based on the episodic and/or prophylactic replacement of clotting factor concentrates.1–3 Despite an increase in treatment advances in recent years, hemophilia remains associated with a high prevalence of disabilities and mortality in many countries.2,4,5 One of the factors that may influence this finding is compliance with the hemophilia treatment protocol, which may be due to problems related either to the patient or healthcare professional adherence to the protocol recommendations. In addition to other chronic diseases, such as diabetes mellitus and systemic arterial hypertension, a challenge for healthcare professionals is ensuring that patients comply with their treatments. It is known that most chronic diseases require multidisciplinary team care.6–9 A recent study carried out in the United States showed that nonattendance at scheduled visits to a hemophilia treatment center (HTC) was associated with increased visits to the emergency department and hospitalizations.10

Brazil has the world’s fourth-largest population of hemophilic patients (10,395 patients with hemophilia A and 2037 with hemophilia B), according to the Annual Global Survey 2017 of the World Federation of Hemophilia, after the United States, India, and China.11 In Brazil, the Unified Health System (SUS) is responsible for providing free universal public coverage of healthcare services for the entire population.12 Regarding hemophilia care, the Brazilian Ministry of Health has implemented public policies to improve treatment, especially by making higher investments mainly in the acquisition and the regular free-of-charge distribution of plasma-derived or recombinant coagulation factors, aiming to reduce the risks of complications.4,13–16

Thus, this study aimed (i) to identify compliance with a treatment protocol among adult patients with hemophilia and (ii) to evaluate the factors associated with and impact on mortality of noncompliance with a hemophilia treatment protocol.

Methods

Patients

This study was a cross-sectional study performed between June 2015 and May 2016, followed by a cohort to evaluate mortality until July 2019. All patients aged >18 years with hemophilia A or B registered since 2012 in the Brazilian Unified Health System in the Federal District, Brazil, according to the Brazilian registry of people with hereditary coagulopathies (National Hemovida System of Coagulopathies), was included.16

The Ethics Committee of the Education and Research Foundation of Health Sciences (FEPECS), Brasília, Federal District, Brazil approved the study that was conducted following the Declaration of Helsinki. Since the study was observational, without any specific intervention, using only anonymized medical records’ data and other institutional clinical information that generated results in an aggregate manner, and does not allow the identification of research participants, the written consent was not necessary according to the Resolution of the Brazilian National Research Ethics Council.

Data Collection

Patient age, type of hemophilia (A or B), severity of hemophilia (mild, moderate or severe), treatment at an HTC, medical consultations per year, type of treatment (prophylactic or on-demand), dose and type of clotting factor (recombinant or plasma-derived coagulation factor), inhibitor antibody tests, and serological tests for infectious diseases (Chagas disease antibody, total hepatitis B core antibody – anti-HBc, hepatitis B surface antigen – HbsAg, hepatitis B surface antibody - anti-HBs, anti-hepatitis C virus antibody - anti-HCV, anti-human T-cell lymphotropic virus types 1 and 2 antibody – anti-HTLV-1/2, and anti-human immunodeficiency antibody - anti-HIV) were collected from medical records. All serological tests for infectious diseases were performed by the chemiluminescence method (Abbott®), which were processed at the Brasília Hemocentro Foundation as part of the hemophilia treatment protocol.

Hemophilia severity was defined based on the lowest factor VIII or IX plasma residual activity: severe hemophilia when clotting factor levels were below 1%, moderate hemophilia when levels were between 1% and 5%, and mild hemophilia when levels were above 5% up to 40%.3

The Brasília Hemocentro Foundation (BHF) is the HTC for the treatment of inherited coagulation disorders in the Federal District, Brazil. In the last eight years, the BHF implemented several improvements in the healthcare of patients with hemophilia, such as the implementation of the treatment protocol that promotes comprehensive care by a multidisciplinary team with medical, psychological, and physical therapy consultations, a hemostasis laboratory, and pharmaceutical support with home delivery. This protocol includes recommendations for frequency of multidisciplinary team consultations (at least 1 per year for mild hemophilia and 2 per year for moderate/severe hemophilia), type of treatment (prophylaxis or on-demand according to hemophilia severity), type and doses of clotting factor prescription (recombinant factor VIII is indicated for patients until 30 years old and plasma-derived factor for patients above 30 years old), and a laboratory test schedule.

In this study, compliance with the hemophilia treatment protocol was defined through the following checklist:

  1. Medical consultations: number of medical consultations in agreement with the recommended amount over the previous year (at least once a year for patient with mild haemophilia, and at least every 6 months for moderate and severe haemophilia)
  2. Clotting factor regime: type of treatment (prophylactic or on-demand), dose of clotting factor (UI/Kg and weekly frequency of coagulation factor injections), and type of clotting factor (recombinant or plasma-derived coagulation factor) in agreement with the protocol recommendations.
  3. Serological tests: number of tests for infectious diseases and inhibitor antibodies according to the recommended number over the previous year (at least once a year)

Failure to comply with any of the items was considered noncompliant with the protocol treatment.

Statistical Analysis

Quantitative data are expressed as the mean ± standard deviation (SD) or as the median and interquartile range (25–75th percentile) according to their distribution assessed by the Kolmogorov–Smirnov test. Categorical variables are expressed as numbers and percentages (%). Student’s t-test or the Mann–Whitney test was used to compare quantitative variables, as appropriate. Contingency tables were used for categorical variables, and Pearson’s chi-square test (χ2) or Fisher’s exact test was used, as appropriate. To evaluate independent factors associated with noncompliance with the protocol, noncollinear variables associated with noncompliance with the protocol with a p-value <0.20 in the univariate analysis were assessed using backward stepwise logistic regression analysis. Statistical analyses were performed using IBM Statistical Package for Social Sciences 20.0 for Mac (SPSS 20.0 Mac, SPSS Inc., Chicago, Illinois, USA). The level of statistical significance was defined as a two-sided P-value <0.05.

Results

The study included 138 adult patients with hemophilia, mainly hemophilia A (75.4%, 104/138). Table 1 shows the baseline data. The mean age of enrolment in the study was 36.4 ± 12.5 years. Severe hemophilia was the most common (76.8%, 106/138), and 35 patients were compliant with all items of the treatment protocol (25.4%). Regarding each aspect of the protocol individually, compliance with medical consultations, clotting factor regimen, and serological tests were 71.0% (98/138), 65.9% (91/138), and 51.4% (71/138), respectively. The mortality rate during the study period was 7.2% (10/138). Regarding the causes of death, 60% occurred due to spontaneous hemorrhage (6/10), 10% due to liver cancer (1/10), 10% due to lymphoma (1/10), and 10% due to sepsis (1/10). The cause of death was unknown in one patient (10%, 1/10).

Table 1 Baseline Data of Adult Patients with Hemophilia (n = 138)

Table 2 compares compliant and noncompliant patients to the protocol. In the univariate analysis, a statistically significant association was observed between compliance with the protocol and treatment at the HTC (p=0.018). No other statistically significant differences were found when comparing the groups regarding age, severity or type of hemophilia, presence of inhibitors, and serologies for infectious diseases. Using multivariate analysis, treatment in the HTC (p = 0.037) remained associated with compliance with the protocol.

Table 2 Analysis (Univariate and Multivariate) of the Factors Associated with Compliance with the Treatment Protocol in Adult Patients with Hemophilia

Table 3 shows that treatment in the HTC (OR: 2.388; 95% CI: 1.052–5.418) resulted in a positive and independent association with compliance with the protocol in multivariate analysis.

Table 3 Final Multivariate Analysis of Factors Associated with Compliance of the Treatment Protocol in Adult Patients with Hemophilia

Table 4 shows that the number of items in compliance with the treatment protocol was associated with mortality (p<0.001). All deaths occurred in patients who were noncompliant with the protocol. Noncompliance with any aspect of the protocol was associated with mortality: medical consultations (p<0.001), clotting factor regimen (p=0.013), and serological tests (p=0.006). The group that did not comply with all items of the protocol showed the highest mortality (50.0%, 5/10).

Table 4 Compliance with the Protocol and Mortality in Adult Patients with Hemophilia

Discussion

This study found that noncompliance with the treatment protocol remains high in adults with hemophilia, even in a country that has been implementing public health policies to improve the treatment and provides public healthcare assistance and free-of-charge distribution of coagulation factors to hemophilic patients, such as Brazil.4,12,15,17 In other studies, the level of compliance ranged from 43% to 87%, but they evaluated different aspects of hemophilia treatment, mainly adherence to prophylactic treatment, and included children and adolescents.17–21 The present study showed a much lower rate of compliance, but it evaluated other aspects of the treatment protocol in addition to the adherence to clotting factor treatment prescribed and included only adults that are associated with a higher chance of noncompliance than younger age patients.17–19,22 Since our study only included adult patients, this aspect may be related to the no association observed between age and compliance in the present study.

Although the compliance with all protocol items in the present study was only 25.4%, there was great variation between the different aspects evaluated, from 51.4% for serological tests to 71.0% for medical consultations. The compliance with the clotting factor regimen was 65.9%. A Dutch study evaluating the adherence to coagulation factor doses prescribed showed 43% adherence in patients’ self-administration, 63% adherence in parents administration, 37% suboptimal adherence in patients, and 29% adherence in parents administration.19 Another study showed higher adherence to coagulation factors prescribed from 80% to 87% in six European countries.18 In the United Kingdom, a study evaluating only adolescents and young adults with severe hemophilia showed high compliance, with only 18% that self-reported missing prophylaxis doses.17 Regarding medical consultations, a study showed that 12% of patients did not attend scheduled appointments at a United States HTC.10 In general, when comparing the studies, compliance was high in countries where healthcare systems are mostly public.17–21,23 Indeed, a United States study showed that the cost was mentioned by 45% of hemophilia nurses as a major barrier to prophylaxis adherence.22 However, our study showed low compliance with the protocol even in a country that has adopted a public healthcare system with free and universal coverage for its population, including treatment with high-cost products, which shows that other factors are also important.4,12,16,17

Protocols are essential to achieve better physical and psychosocial health and quality of life, focusing on relevant aspects, such as monitoring pharmacological treatment, bleeding, and the presence of inhibitors. Additionally, scheduled appointments as part of the protocol are opportunities for health promotion and prevention of harm.3,10 Although the high rate of nonadherence observed in our study may also be occurring in other Brazilian regions, a recent study showed a progressive decrease in the mortality of patients with hemophilia in Brazil,2 which may be related to the improvement in hemophilia care due to Brazilian healthy public policies in recent years.2 However, this result could be even better if new strategies were adopted, aiming to promote greater treatment protocol compliance, especially when all deaths occurred in patients who were noncompliant with protocol in our study.

In this article, most deaths occurred due to bleeding. Hemorrhage and its complications are still the main causes of death in hemophilia, as shown in recent studies.2,21,24–26 Regarding the association between the incidence of hemorrhagic events and noncompliance with the protocol, a study that evaluated nonattendance at appointments scheduled in the United States HTC showed there was an association between nonattendance and consultations in emergency services and hospitalizations.10 A study showed that nonadherence to prophylaxis was associated with the number of hemarthrosis in patients with hemophilia aged 12 to 25 years.21 Indeed, a study in children and adolescents from 33 HTCs in 20 countries found that regular and frequent prophylaxis decreased the risk of intracranial hemorrhage compared with infrequent or non-existent prophylaxis.27 These studies suggest that when patients are not submitted to regular clinical follow-up, they are at high risk for acute events, such as bleeding.

For the development of new policies that aim to promote improvement in compliance with the protocol, it is important to recognize the factors associated with noncompliance in hemophilic patients. In this study, noncompliance with the clinical treatment protocol was associated with nontreatment in an HTC, which may show the importance of comprehensive care by a multidisciplinary team and family support. Hemophilia is a rare disease with complex treatment. In this sense, health professionals must have the knowledge and experience to address the peculiarities of the treatment of hemorrhagic disorders. These patients need comprehensive care by a multidisciplinary team, who can promote better physical and psychosocial health, in addition to ensuring continuity of care.1,12,28 Moreover, compliance with the treatment protocol is a complex and multidimensional phenomenon that is influenced by multiple aspects, such as clinical, personal, social, and organizational factors.17,29,30 Thus, comprehensive multidisciplinary care at an HTC is essential to promote patient compliance, as demonstrated in the present study, which found greater compliance in the protocol in patients treated at an HTC. A European survey showed that the time spent at an HTC and the quality of the relationship with the hematologist and the nurse were associated with greater adherence to treatment in hemophilia.18 Additionally, the implementation of an HTC decreased costs and improved patient outcomes in different studies,29,31–33 and patients who had undergone care in an HTC had a significant reduction in the risk of death.29,32

No other factor evaluated in this study, such as age and severity or type of hemophilia, was independently associated with nonadherence to the treatment protocol. Regarding age, it is important to note that our study only evaluated adults, and previous studies reported higher compliance among children and adolescents than among adults.17–21 As in other chronic diseases, the association between disease severity and protocol compliance remains uncertain.10,34,35 A North American study showed no association between the severity of the disease and the failure to attend scheduled appointments, one aspect of compliance evaluated in the present study.10

There are limitations to our study. Hemophilia is a rare disease, and therefore, it is difficult to have a large cohort. This study did not measure other potential characteristics for compliance with the protocol, such as between educational level, income, health status, access to transportation, and the quality of the relationship with the patient and multidisciplinary team. In this respect, the educational level and low income of the majority of the Brazilian population are still factors to be considered concerning the understanding of hemophilia and how the healthcare system is organized in Brazil. Given this reality, in 2011, BHF started delivering coagulation factors to the home, accompanied by psychosocial assessment and guidance on the storage and application of the products by nurses, pharmaceutics, and social workers. Due to the peculiarities of treatment in adults and children, like the care given by parents to patients, we decided included only adults in the present study, so our results should only be generalized to patients aged >18 years. Finally, it was not possible to perform a multivariate analysis to assess the outcome of mortality, since the number during the study period was insufficient.

Conclusion

Noncompliance with the protocol was high in this group of adult patients with hemophilia. Compliance with the treatment protocol was positively and independently associated with treatment at the HTC. All deaths occurred in patients who did not comply with the protocol, and the majority were due to bleeding. Among the deaths, 50% of the patients did not comply with any item of the protocol, and the other 50% of the deaths fulfilled only one or two items of the protocol. These results reinforce the importance of care by a multidisciplinary team, and the preventive treatment and protocol.

All members of the healthcare team should be aware of strategies to promote the continuous improvement of the treatment and patient compliance with the protocol. Preventive efforts should be focused on minimizing the occurrence of bleeding, especially with the correct application of the treatment protocol and monitoring of patients by a multidisciplinary team.

Disclosure

The authors report no conflicts of interest for this work.

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