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Expression Of Cyclin D1 Protein Isoforms And Its Prognostic Significance In Cervical Cancer

Authors Gu J, Zhang X, Yang Z, Wang N

Received 21 July 2019

Accepted for publication 19 September 2019

Published 24 October 2019 Volume 2019:11 Pages 9073—9083

DOI https://doi.org/10.2147/CMAR.S224026

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo


Jiahui Gu,1 Xinyu Zhang,2 Zhuo Yang,1 Ning Wang1

1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110001, People’s Republic of China; 2Department of Obstetrics and Gynecology, Daqing People’s Hospital, Daqing, Heilongjiang Province 163711, People’s Republic of China

Correspondence: Ning Wang
Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Sanhao Street No. 36, Heping District, Shenyang, Liaoning, People’s Republic of China
Email nonaware@sina.com

Introduction: Cyclin D1 had been associated with different clinical and pathological stages of cervical cancer; however, few studies had focused on its correlation with cervical cancer prognosis. Therefore, this study aimed to assess the expression of cyclin D1a and D1b in normal tissue, cervical cancer and cervical intraepithelial neoplasia and their effect on prognosis.
Methods: Expression of cyclin D1a and D1b was detected by immunohistochemical staining in 78 cases of primary cervical cancer, 40 cases of cervical intraepithelial neoplasia, and 40 cases of normal cervical tissue.
Results: No significant difference was observed in the expression of cyclin D1a between normal and cervical cancer tissues (P = 0.201); however, its expression was significantly higher in cervical cancer than in cervical intraepithelial neoplasia tissues (P = 0.000). Expression of cyclin D1b was higher in normal tissues than in cervical cancer tissues (P = 0.000). No significant difference was observed in the expression of cyclin D1a in cervical cancer tissues with respect to age, pathological type, clinical-stage, depth of tumor invasion, or presence of lymph node metastases (P = 0.111,0.119,0.539,0.084,0.539). COX survival analysis showed that lymph node metastasis might be an independent factor affecting postoperative recurrence (hazard risk [HR] = 0.240; 95% confidence interval [CI] = 0.968–30.156; P = 0.034).
Discussion: Cyclin D1a expression was associated with tumor tissue size and degree of differentiation. The expression of cyclin D1b in cervical cancer was associated with the presence of lymph node metastases. Cyclin D1a and D1b expression in cervical cancer tissue was significantly correlated. Cox survival analysis showed that the presence of lymph node metastases might serve as an independent factor affecting postoperative recurrence. The expression of cyclin D1a and D1b was not associated with cervical cancer prognosis.
Conclusion: Assessment of cyclin D1a and D1b expression in cervical cancer and cervical intraepithelial neoplasia revealed that cyclin D1 could not be used as a reference to assess cervical cancer patient prognosis.

Keywords: cyclin D1 protein isoforms, cervical cancer, expression, prognosis


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