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Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort

Authors Reznitsky M, Petersen MMBS, West N, Stangerup SE, Cayé-Thomasen P

Received 7 June 2019

Accepted for publication 20 August 2019

Published 8 November 2019 Volume 2019:11 Pages 981—986

DOI https://doi.org/10.2147/CLEP.S218670

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Vera Ehrenstein


Martin Reznitsky,1 Mette Marie Babiel Schmidt Petersen,1 Niels West,1,2 Sven-Eric Stangerup,1 Per Cayé-Thomasen1,2

1The Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 2Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Correspondence: Martin Reznitsky
Rigshospitalet, Copenhagen University Hospital, Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Blegdamsvej 9, Copenhagen Ø 2100, Denmark
Tel +45 3545 7877
Email martin.reznitsky@gmail.com

Objective: Reports on the epidemiology of vestibular schwannoma (VS) indicate an increase in diagnosed cases, often based on selected materials over a limited period of time. This report presents prospective 40-year epidemiological data from an unselected national cohort of all patients diagnosed with a VS in Denmark since 1976.
Study-design: Data on gender, age, tumor localization and size registered during the period 1976–2015 were retrieved.
Results: 3637 new cases of VS were diagnosed during the 40-year period. The annual number of diagnosed VS increased from 14 in 1976 to 193 in 2015. Mean extrameatal tumor size decreased from 26mm in 1976 to 13.4mm in 2015. Large and giant tumors were more frequent during the first decades, whereas predominantly smaller tumors were diagnosed during the recent years. Median age at diagnosis increased gradually from 49.2 years in 1976 to 60 years in 2015.
Conclusion: Over the past 40 years, the incidence rate of vestibular schwannomas has increased steadily from 3 VS/million/year to 34 VS/million/year, primarily due to easier access to improved diagnostics and the finding of more tumors in older people. Concurrently, the diagnostic tumor size has decreased from 26mm to 7mm, and the age at diagnosis has increased from 49 to 60 years.

Keywords: acoustic neuroma, age, incidence, tumor localization, tumor size

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