Back to Journals » International Journal of Women's Health » Volume 11

Engaging study participants in interpreting results: lessons from the TRIO study in Kenya and South Africa

Authors Agot K, Minnis AM, Manenzhe K, Browne EN, Ahmed K, Okello T, van der Straten A

Received 8 November 2018

Accepted for publication 25 February 2019

Published 12 July 2019 Volume 2019:11 Pages 395—403


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Elie Al-Chaer

Kawango Agot,1 Alexandra M Minnis,2 Kgahlisho Manenzhe,3 Erica N Browne,2 Khatija Ahmed,3 Timothy Okello,1 Ariane van der Straten2

1Impact Research and Development Organization, Kisumu, Kenya; 2Women’s Global Health Imperative, RTI International, San Francisco, CA, USA; 3Setshaba Research Centre, Soshanguve, South Africa

Background: Women account for 56% of new HIV infections in sub-Saharan Africa. Multipurpose Prevention Technologies (MPTs) are promising interventions because they combine HIV prevention with a less stigmatizing indication, such as pregnancy. We conducted a study with three placebo-only MPT products in Kisumu, Kenya and Soshanguve, South Africa, to assess preferences for attributes of tablets, vaginal rings and injectable products for dual prevention of HIV and pregnancy (TRIO Study). Here, we present former TRIO participants’ views on the study results.
Methods: After study completion in 2017, we held five dissemination sessions (two in Kisumu and three in Soshanguve) and five one-on-one sharing sessions in Soshanguve. Key results were discussed, with a focus on why some study products were more popular than others, which findings were surprising and why some women changed products over time. A thematic approach was used for analysis.
Results: All 277 TRIO participants were telephoned, 168 (60.6%) were reached and 117 (42.2%) attended the dissemination sessions: 71 in Kisumu and 46 in Soshanguve. Participants were engaged and interested in the TRIO findings and willingly shared their perspectives and views candidly. Ease of use, discretion and familiarity were highlighted as drivers of product choice whereas novelty presented a challenge. In explaining the discrepancy between preference ratings and choices, participants cited features such as tablets being easy to explain to a partner or to discontinue. In explaining why 20% of participants switched products after practical experience, issues related to relationships with partners and product attributes perceived as unfavorable were paramount.
Conclusion: The dissemination sessions provided an important forum for study participants to interrogate and explain the results to minimize possible misinterpretation. This exercise helped give context to the results, ensured correct lessons were derived from those results and increased credibility of the findings reported by the investigators.

Keywords: end-user research, MPT products, community-engaged research, biomedical HIV prevention

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Download Article [PDF]  View Full Text [HTML][Machine readable]