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Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration

Authors Jin S, Li J, Wang J, Jiang J, Zuo Y, Li Y, Yang F

Received 10 March 2018

Accepted for publication 18 June 2018

Published 10 August 2018 Volume 2018:13 Pages 4591—4605

DOI https://doi.org/10.2147/IJN.S167793

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Shue Jin,1 Jidong Li,1 Jian Wang,1 Jiaxing Jiang,1 Yi Zuo,1 Yubao Li,1 Fang Yang2

1Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China; 2Department of Biomaterials, Radboud University Medical Center, Nijmegen, the Netherlands

Purpose: The purpose of this study is to construct a guided bone regeneration membrane that is similar to bone components and structurally resembles the native extracellular matrix with sufficient antibacterial properties.
Materials and methods: A novel type of biomimetic and bioactive silver ion-loaded calcium phosphate/chitosan (Ag-CaP/CS) membrane with antibacterial ability was successfully developed by incorporation of silver ion-loaded CaP via a one-step electrospinning method and subsequently crosslinked with vanillin.
Results: Evaluation of the physicochemical properties revealed that the fabricated fibrous membranes mimicked the extracellular matrix structure and the addition of CaP significantly increased the mineralization ability of the membranes. Importantly, the Ag-CaP/CS membranes exhibited a sustainable release of Ag+, which in turn inhibited the adhesion and growth of Staphylococcus mutans. The results of cell adhesion and MTT assay revealed that the Ag-CaP/CS membranes were cytocompatible with bone marrow stromal cells.
Conclusion: The fabricated electrospinning Ag-CaP/CS nanofiber membranes with excellent biocompatibility and strong antimicrobial properties have great potential to be used for guided bone regeneration.

Keywords: antimicrobial, electrospinning, chitosan, membrane, guided bone regeneration

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