Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Effects of graphene plates’ adoption on the microstructure, mechanical properties, and in vivo biocompatibility of calcium silicate coating

Authors Xie YT, Li HQ, Ding CX, Zheng XB, Li K

Received 21 November 2014

Accepted for publication 16 February 2015

Published 8 June 2015 Volume 2015:10(1) Pages 3855—3863

DOI https://doi.org/10.2147/IJN.S77919

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang

Youtao Xie, Hongqin Li, Chuanxian Ding, Xuebin Zheng, Kai Li

Shanghai Institute of Ceramics, Key Laboratory of Inorganic Coating Materials, Chinese Academy of Sciences, Shanghai, People’s Republic of China


Abstract: Calcium silicate (CS) ceramic is a good coating candidate for biomedical implants to improve biocompatibility and accelerate early osseo-integration. However, the poor fracture toughness and wear resistance of this ceramic material restricts the long-term performance of implants. In this study, graphene plates (GPs) were used as reinforcement to improve the mechanical properties of CS coating. Composite coating containing 1.5 weight % GPs was prepared by vacuum plasma spraying technology. The good survival of the GPs in the composite coating was demonstrated by Raman analysis, although the defects of the GPs were increased after plasma spraying. Effects of the GPs’ adoption on the microstructure of the coating were studied by scanning electron microscopy and transmission electron microscopy. Results showed that the GPs were homogenously distributed in the CS grains interface or enwrapped on the particles, and exhibited good wetting behavior with the CS matrix. The wear properties of the composite coating were obviously enhanced by the reinforcement of GPs. The reinforcement mechanism was attributed to the enhanced micro-hardness and interfacial bonding of the particles in the coating. In vivo experiments demonstrated that the composite coating possessed similarly good biocompatibility compared to pure CS coating. The bone-implant contact ratio reached 84.3%±7.4% for GPs/CS coating and 79.6%±9.4% for CS coating after 3 months’ implantation.

Keywords: graphene plates, coating, microstructure, wear resistance, biocompatibility

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Wear studies on plasma-sprayed Al2O3 and 8mole% of Yttrium-stabilized ZrO2 composite coating on biomedical Ti-6Al-4V alloy for orthopedic joint application

Ganapathy P, Manivasagam G, Rajamanickam A, Natarajan A

International Journal of Nanomedicine 2015, 10:213-222

Published Date: 1 October 2015

Enhancement of bioactivity of titanium carbonitride nanocomposite thin films on steels with biosynthesized hydroxyapatite

Thampi VV, Dhandapani P, Manivasagam G, Subramanian B

International Journal of Nanomedicine 2015, 10:107-118

Published Date: 1 October 2015

Tuning the surface microstructure of titanate coatings on titanium implants for enhancing bioactivity of implants

Wang H, Lai YK, Zheng RY, Bian Y, Zhang KQ, Lin CJ

International Journal of Nanomedicine 2015, 10:3887-3896

Published Date: 8 June 2015

Formulation optimization of galantamine hydrobromide loaded gel drug reservoirs in transdermal patch for Alzheimer’s disease

Woo FY, Basri M, Fard Masoumi HR, Ahmad MB, Ismail M

International Journal of Nanomedicine 2015, 10:3879-3886

Published Date: 5 June 2015

Mesoporous bioactive glass surface modified poly(lactic-co-glycolic acid) electrospun fibrous scaffold for bone regeneration

Chen SJ, Jian ZY, Huang LS, Xu W, Liu SH, Song DJ, Wan ZM, Vaughn A, Zhan RS, Zhang CY, Wu S, Hu MH, Li JS

International Journal of Nanomedicine 2015, 10:3815-3827

Published Date: 2 June 2015

Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application

Villatte G, Massard C, Descamps S, Sibaud Y, Forestier C, Awitor KO

International Journal of Nanomedicine 2015, 10:3367-3375

Published Date: 6 May 2015

Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection

Li B, Zhang XY, Yang JZ, Zhang YJ, Li WX, Fan CH, Huang Q

International Journal of Nanomedicine 2014, 9:4697-4707

Published Date: 8 October 2014

Electrospun vancomycin-loaded coating on titanium implants for the prevention of implant-associated infections

Zhang L, Yan JW, Yin ZW, Tang C, Guo Y, Li D, Wei B, Xu Y, Gu QR, Wang LM

International Journal of Nanomedicine 2014, 9:3027-3036

Published Date: 23 June 2014

In vivo and in vitro investigations of a nanostructured coating material – a preclinical study

Adam M, Ganz C, Xu W, Sarajian HR, Götz W, Gerber T

International Journal of Nanomedicine 2014, 9:975-984

Published Date: 14 February 2014