Effect of SARS-CoV-2 Infection on the Microbial Composition of Upper Airway
Authors Wang Z, Hu X, Li Z, Tu C, Wang Y, Pang P, Zhang H, Zheng X, Liang Y, Shan H, Liu J
Received 30 April 2020
Accepted for publication 5 July 2020
Published 31 July 2020 Volume 2020:13 Pages 2637—2640
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 4
Editor who approved publication: Professor Suresh Antony
Zhenguo Wang1 *, Xiaojun Hu2 *, Zhonghe Li3 *, Changli Tu,1 Yiming Wang,4 Pengfei Pang,2 Huitao Zhang2 *, Xiaobin Zheng,1 Yingjian Liang,1 Hong Shan,2 Jing Liu1
1Department of Pulmonary and Critical Care Medicine (PCCM), The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of China; 2Department of Center for Interventional Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of China; 3Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of China; 4Department of Huada Joint Laboratory, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Liu; Hong Shan
Fifth Affiliated Hospital of Sun Yat-sen University, 52 East Meihua Road, Zhuhai City 519000, People’s Republic of China
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Methods:: Forty-four COVID-19 patients (severe/critical: N = 8, non-severe: N = 36) were examined by next generation sequencing (NGS) of nasopharyngeal test paper to observe the effect of novel coronavirus infection to the microbial composition in upper airway.
Results: In these nasopharyngeal test paper samples, 38 kinds of bacteria, 10 kinds of viruses except SARS-CoV-2, nine kinds of fungi and three kinds of atypical pathogens had been found. There was some difference in microbial composition in the upper airway between severe and non-severe cases.
Summary: These results are important for us to study the effect of SARS-CoV-2 on the local microbial composition of upper airway and prevent opportunistic infection in severe patients.
Keywords: SARS-CoV-2, microbial composition, upper airway, next generation sequencing; NGS
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