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Durable response using regorafenib in an elderly patient with metastatic colorectal cancer: case report

Authors Tang R, Kain T, Herman J, Seery T

Received 1 July 2015

Accepted for publication 17 August 2015

Published 19 November 2015 Volume 2015:7 Pages 357—360

DOI https://doi.org/10.2147/CMAR.S91547

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Giandomenico Roviello

Peer reviewer comments 2

Editor who approved publication: Professor Kenan Onel

Ronald Tang,1 Tatiana Kain,2 June Herman,2 Tara Seery1

1Division of Hematology-Oncology, 2Division of Nuclear Medicine and Molecular Imaging, University of California, Irvine, Orange, CA, USA

Abstract: Regorafenib, an oral multikinase inhibitor, was approved in September 2012 by the US Food and Drug Administration for the treatment of patients with metastatic colorectal cancer. Since this time, however, few case reports outlining real-world usage have been published in the literature. Here, we detail the clinical history of an elderly woman with KRAS wild-type colon cancer who received regorafenib after prior treatment with other agents. We show that by employing dose modification strategies to address adverse events, this patient was able to remain on therapy for 11 months and achieve stable disease.

Keywords: regorafenib, metastatic colorectal cancer, oral multikinase inhibitor

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