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Distinct pain profiles in patients with chronic obstructive pulmonary disease

Authors Bentsen SB, Miaskowski C, Cooper BA, Christensen VL, Henriksen AH, Holm AM, Rustøen T

Received 28 August 2017

Accepted for publication 28 December 2017

Published 6 March 2018 Volume 2018:13 Pages 801—811

DOI https://doi.org/10.2147/COPD.S150114

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Charles Downs

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell


Signe B Bentsen,1 Christine Miaskowski,2 Bruce A Cooper,3 Vivi L Christensen,4,5 Anne H Henriksen,6 Are M Holm,7,8 Tone Rustøen5,9

1Department of Quality and Health Technology, Faculty of Health Sciences, University of Stavanger, Stavanger, Norway; 2Department of Physiological Nursing, University of California, San Francisco, CA, USA; 3Department of Community Health Systems, University of California, San Francisco, CA, USA; 4Department of Master and Postgraduate Studies, Lovisenberg Diaconal University College, Oslo, Norway; 5Department of Research and Development, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway; 6Department of Circulation and Medical Imaging, St Olav’s University Hospital, Trondheim, Norway; 7Department of Respiratory Medicine, Oslo University Hospital, Oslo, Norway; 8Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 9Department of Nursing Science, Institute of Health and Society, University of Oslo, Oslo, Norway

Background: Few studies have examined changes in the pain experience of patients with COPD and predictors of pain in these patients.
Objectives: The objectives of the study were to examine whether distinct groups of COPD patients could be identified based on changes in the occurrence and severity of pain over 12 months and to evaluate whether these groups differed on demographic, clinical, and pain characteristics, and health-related quality of life (HRQoL).
Patients and methods: A longitudinal study of 267 COPD patients with very severe COPD was conducted. Their mean age was 63 years, and 53% were females. The patients completed questionnaires including demographic and clinical variables, the Brief Pain Inventory, and the St Georges Respiratory Questionnaire at enrollment, and 3, 6, 9, and 12 months follow-up. In addition, spirometry and the 6 Minute Walk Test were performed. Latent class analysis was used to identify subgroups of patients with distinct pain profiles based on pain occurrence and worst pain severity.
Results: Most of the patients (77%) reported pain occurrence over 12 months. Of these, 48% were in the “high probability of pain” group, while 29% were in the “moderate probability of pain” group. For the worst pain severity, 37% were in the “moderate pain” and 39% were in the “mild pain” groups. Females and those with higher body mass index, higher number of comorbidities, and less education were in the pain groups. Patients in the higher pain groups reported higher pain interference scores, higher number of pain locations, and more respiratory symptoms. Few differences in HRQoL were found between the groups except for the symptom subscale.
Conclusion: Patients with COPD warrant comprehensive pain management. Clinicians may use this information to identify those who are at higher risk for persistent pain.

Keywords: chronic obstructive pulmonary disease, patient-reported outcomes, pain, pain occurrence, worst pain severity, latent profile analysis

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