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Dissociative states in borderline personality disorder and their relationships to psychotropic medication

Authors Pec O, Bob P, Simek J, Raboch J

Received 4 July 2018

Accepted for publication 24 September 2018

Published 23 November 2018 Volume 2018:14 Pages 3253—3257

DOI https://doi.org/10.2147/NDT.S179091

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Ondrej Pec,1,2 Petr Bob,1,3 Jakub Simek,1 Jiri Raboch1

1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 2Psychotherapeutic and Psychosomatic Clinic ESET, Prague, Czech Republic; 3Central European Institute of Technology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

Background: According to recent data, dissociation may play an important role in borderline personality disorder (BPD), nevertheless specific influences of psychotropic medication on dissociative symptoms in BPD and their therapeutic indications are largely unknown. The purpose of this study was to assess relationships of dissociative symptoms in BPD patients with levels of psychotropic medication and compare these results with a subgroup of patients with schizophrenia.
Materials and methods: In this study, we investigated 52 BPD patients and compared the results with a control group of 36 schizophrenia patients. In all participants, we assessed actual day doses of antipsychotic medication in chlorpromazine equivalents and antidepressant medication in fluoxetine equivalents. Dissociative symptoms were measured by Dissociative Experiences Scale (DES), and other psychopathological symptoms were measured using Health of the Nation Outcome Scales.
Results: Results indicate that dissociative symptoms measured by DES were significantly correlated with antipsychotic medication (Spearman R=0.45, P<0.01) in chlorpromazine equivalents and antidepressant medication in fluoxetine equivalents (0.36, P<0.01). These relationships between medication and dissociative symptoms were not found in the control group of schizophrenia patients.
Conclusion: The results suggest that levels of antipsychotic medication and antidepressant medication are significantly associated with dissociative symptoms in BPD but not in schizophrenia.

Keywords: dissociation, stress, antipsychotics, antidepressants

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