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Differential drug effects on spontaneous and evoked pain behavior in a model of trigeminal neuropathic pain

Authors Deseure K, Hans GH

Received 12 October 2016

Accepted for publication 16 November 2016

Published 27 January 2017 Volume 2017:10 Pages 279—286


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Michael Schatman

K Deseure,1 GH Hans2

1Department of Medicine, Laboratory for Pain Research, University of Antwerp, Wilrijk, 2Multidisciplinary Pain Center, Antwerp University Hospital, Edegem, Belgium

Baclofen and morphine have shown efficacy against mechanical allodynia after infraorbital nerve chronic constriction injury (IoN-CCI). No drug effects have yet been reported on spontaneous trigeminal neuropathic pain. It has been proposed that the directed face grooming behavior that also develops following IoN-CCI offers a measure of spontaneous trigeminal neuropathic pain.
Subjects and methods:
We examined the effects of a continuous 1-week infusion of 30 mg/day carbamazepine (the first-line drug treatment for trigeminal neuralgia), 1.06 mg/day baclofen, 4.18 mg/day clomipramine, and 5 mg/day morphine on spontaneous and mechanically evoked pain behavior (ie, directed face grooming and von Frey testing) in IoN-CCI rats.
Results: Isolated face grooming was significantly reduced in rats receiving carbamazepine and baclofen but not in clomipramine- or morphine-treated rats. All drugs showed significant antiallodynic effects; carbamazepine showed the strongest effects, whereas clomipramine had only minor efficacy.
Conclusion: The tested drugs have differential effects in the IoN-CCI model, and different neuropathological mechanisms may underlie the different somatosensory symptoms in this model. A mechanism-based approach may be needed to treat (trigeminal) neuropathic pain. The present data support IoN-CCI as a model of trigeminal neuralgia in which isolated face grooming is used as a measure of spontaneous neuropathic pain.

Keywords: trigeminal, infraorbital, neuropathic, allodynia, chronic, grooming

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