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Dermal benefits of topical D-ribose

Authors Shecterle LM, St.Cyr J

Published 9 September 2009 Volume 2009:2 Pages 151—152

DOI https://doi.org/10.2147/CCID.S7487

Review by Single anonymous peer review

Peer reviewer comments 4

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Linda M Shecterle, John A St. Cyr

Jacqmar, Inc., Minneapolis, MN, USA

Abstract: Our aging skin undergoes changes with reductions in collagenous and elastic fibers, fibroblasts, mast cells, and macrophages with free radical production, which can result in reduced skin tone and wrinkle formation. Fibroblasts are important for dermal integrity and function with a decrease in function producing less skin tone, thinning, and wrinkle formation. Dermal levels of adenosine triphosphate (ATP) decline with aging, potentially altering dermal function. Supplemental D-ribose, a natural occurring carbohydrate, enhances ATP regeneration. D-ribosebased studies demonstrated benefits in both cell culture fibroblastic activities and a subsequent clinical study in women with decreased skin tone with wrinkles. Supplemental D-ribose may offer this needed cellular benefit.

Keywords: dermal, fibroblast, ATP, aging, wrinkles

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