Current perspectives on cadherin-cytoskeleton interactions and dynamics
Authors Liang X, Gomez G, Yap A
Received 20 October 2014
Accepted for publication 2 December 2014
Published 5 January 2015 Volume 2015:7 Pages 11—24
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 3
Editor who approved publication: Professor Denis Wirtz
Xuan Liang, Guillermo A Gomez, Alpha S Yap
Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
Abstract: Cells are linked together dynamically by adhesion molecules, such as the classical cadherins. E-cadherin, which mediates epithelial cell–cell interactions, plays fundamental roles in tissue organization and is often perturbed in diseases such as cancer. It has long been recognized that the biology of E-cadherin arises from cooperation between adhesion and the actin cytoskeleton.
A major feature is the generation of contractile forces at junctions, yielding patterns of tension that contribute to tissue integrity and patterning. Here we discuss recent developments in understanding how cadherin junctions integrate signaling and cytoskeletal dynamics to sense and generate force.
Keywords: E-cadherin, actomyosin, morphogenesis, cell extrusion, wound closure, mechanobiology
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