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Current perspectives on cadherin-cytoskeleton interactions and dynamics

Authors Liang X, Gomez G, Yap A

Received 20 October 2014

Accepted for publication 2 December 2014

Published 5 January 2015 Volume 2015:7 Pages 11—24

DOI https://doi.org/10.2147/CHC.S76107

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Denis Wirtz


Xuan Liang, Guillermo A Gomez, Alpha S Yap

Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia

Abstract: Cells are linked together dynamically by adhesion molecules, such as the classical cadherins. E-cadherin, which mediates epithelial cell–cell interactions, plays fundamental roles in tissue organization and is often perturbed in diseases such as cancer. It has long been recognized that the biology of E-cadherin arises from cooperation between adhesion and the actin cytoskeleton.
A major feature is the generation of contractile forces at junctions, yielding patterns of tension that contribute to tissue integrity and patterning. Here we discuss recent developments in understanding how cadherin junctions integrate signaling and cytoskeletal dynamics to sense and generate force.

Keywords: E-cadherin, actomyosin, morphogenesis, cell extrusion, wound closure, mechanobiology

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