Back to Journals » Drug Design, Development and Therapy » Volume 5

Current and emerging drugs for the treatment of inflammatory bowel disease

Authors Triantafillidis J, Merikas E, Georgopoulos F

Published 6 April 2011 Volume 2011:5 Pages 185—210


Review by Single anonymous peer review

Peer reviewer comments 2

John K Triantafillidis, Emmanuel Merikas, Filippos Georgopoulos
Department of Gastroenterology, Center for Inflammatory Bowel Disease, “Saint Panteleimon” General Hospital, Nicea, Greece

Abstract: During the last decade a large number of biological agents against tumor necrosis factor-α (TNF-α), as well as many biochemical substances and molecules specifically for the medical treatment of patients with inflammatory bowel disease (IBD), have been developed. This enormous progress was a consequence of the significant advances in biotechnology along with the increased knowledge of the underlying pathophysiological mechanisms involved in the pathogenesis of IBD. However, conventional therapies remain the cornerstone of treatment for most patients. During recent years conventional and biologic IBD therapies have been optimized. Newer mesalazine formulations with a reduced pill size and only one dose per day demonstrate similar efficacy to older formulations. New corticosteroids retain the efficacy of older corticosteroids while exhibiting a higher safety profile. The role of antibiotics and probiotics has been further clarified. Significant progress in understanding thiopurine metabolism has improved the effective dose along with adjunctive therapies. Quite a large number of substances and therapies, including biologic agents other than TNF-α inhibitors, unfractionated or low-molecular-weight heparin, omega-3 polyunsaturated fatty acids, microbes and microbial products, leukocytapheresis, and other substances under investigation, could offer important benefits to our patients. In this paper we review the established and emerging therapeutic strategies in patients with Crohn’s disease and ulcerative colitis.

Keywords: inflammatory bowel disease, ulcerative colitis, Crohn’s disease, treatment, biologic agents, immunosuppressives, mesalazine, antibiotics

Creative Commons License © 2011 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.