Back to Journals » Clinical Epidemiology » Volume 10

Effect modification, interaction and mediation: an overview of theoretical insights for clinical investigators [Corrigendum]

Authors Corraini P, Olsen M, Pedersen L, Dekkers OM, Vandenbroucke JP

Received 11 January 2018

Accepted for publication 11 January 2018

Published 1 March 2018 Volume 2018:10 Pages 223—224

DOI https://doi.org/10.2147/CLEP.S162236


Corraini P, Olsen M, Pedersen L, Dekkers OM, Vandenbroucke JP, Clin Epidemiol. 2017;9:331–338.

On pages 333–334, the interaction contrast appeared incorrectly as 1.5 per 1,000 person-years, where it should read –1.5 per 1,000 person-years. This occurred from an inversion between the result of the rate reduction of heart disease due to aspirin among those receiving warfarin (10.3–8.7=1.6) and the result of the rate reduction due to aspirin among those not receiving warfarin (13.3–10.2=3.1).

The interpretation of the interaction contrast should then read in page 334 as: “As the interaction contrast was below zero, it could be concluded that the effect of combining warfarin and aspirin in reducing ischemic heart disease was lower than that expected by the sum of the effects of either agent on its own.”

Read the original article


Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]