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Correlation between Xerostomia index, Clinical Oral Dryness Scale, and ESSPRI with different hyposalivation tests

Authors Hijjaw O, Alawneh M, Ojjoh K, Abuasbeh H, Alkilany A, Qasem N, Al-Essa M, AlRyalat SA

Received 27 September 2018

Accepted for publication 4 December 2018

Published 4 January 2019 Volume 2019:11 Pages 11—18

DOI https://doi.org/10.2147/OARRR.S188937

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Professor Chuan-Ju Liu


Ola Hijjaw,1 Mohammad Alawneh,1 Khaled Ojjoh,1 Hazem Abuasbeh,1 Ahmad Alkilany,1 Nabeel Qasem,1 Mohammad Al-Essa,1 Saif Aldeen AlRyalat2

1Department of Internal Medicine, The University of Jordan, Amman 11942, Jordan; 2Department of Ophthalmology, The University of Jordan, Amman 11942, Jordan

Background and objective: Xerostomia is a subjective measure of dry mouth, while hyposalivation is an objective measure of reduced saliva flow rate. In this study, we aim to assess the association between commonly used xerostomia scoring systems, with different hyposalivation measures among Sjogren Syndrome (SS) patients.
Methods: In a cohort of SS patients, we assessed xerostomia using Xerostomia index, clinical oral dryness scale (CODS), and the European League Against Rheumatism SS Patient-Reported Index (ESSPRI), and we assessed hyposalivation using unstimulated whole saliva flow (UWS), stimulated whole saliva flow (SWS), and stimulated parotid flow (SPF). We analyzed the association between xerostomia and hyposalivation using association tests in SPSS.
Results: We included a total of 49 patients in this study, of which 34 (68%) had primary SS, and 15 (32%) had secondary. CODS was significantly correlated with SWS (P=0.048), with a negative correlation coefficient of 0.216, and with SPF (P=0.009), with a negative correlation coefficient of 0.291. The dryness domain of ESSPRI was significantly correlated with UWS (P=0.031) with a negative correlation coefficient of 0.233.
Conclusion:
CODS is the scoring system with the highest correlation with hyposalivation, particularly SWS and SPF, followed by ESSPRI dry domain, which is correlated with UWS. Xerostomia index is not correlated with hyposalivation.

Keywords: Sjogren syndrome, xerostomia, hyposalivation, XI, CODS, ESSPRI

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