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Correlation between short-term and long-term intraocular pressure fluctuation in glaucoma patients

Authors Tojo N, Abe S, Miyakoshi M, Hayashi A

Received 9 July 2016

Accepted for publication 2 August 2016

Published 2 September 2016 Volume 2016:10 Pages 1713—1717

DOI https://doi.org/10.2147/OPTH.S116859

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Naoki Tojo, Shinya Abe, Mari Miyakoshi, Atsushi Hayashi

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

Purpose: We investigated correlations between short-term and long-term intraocular pressure (IOP) fluctuations.
Methods: We examined 50 eyes of glaucoma patients who were followed for >2 years. We measured short-term IOP fluctuation using a Triggerfish® contact lens sensor (CLS). The short-term IOP fluctuation (mVeq) was defined as the difference between the maximum value and the minimum value measured during the 24-hour course with CLS. The long-term IOP fluctuation was defined by four parameters: 1) the mean IOP (mmHg) determined during follow-up; 2) the IOP difference, which was defined as the difference between the maximum IOP and the minimum IOP; 3) the standard deviation of IOP; and 4) the peak IOP, which was defined as the maximum IOP. Correlations between these parameters and the short-term IOP fluctuation were examined.
Results: The mean follow-up period was 5.4 years. The average IOP was 15.0±4.0 mmHg. The range of short-term IOP fluctuation identified with CLS was significantly correlated with all the four long-term IOP fluctuation parameters.
Conclusion: Short-term IOP fluctuations were found to be associated with long-term IOP fluctuations. Examination of 24-hour IOP fluctuations with the CLS might be useful for predicting the long-term IOP fluctuation.

Keywords: intraocular pressure, contact lens sensor, Triggerfish®, fluctuation

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