Back to Journals » Breast Cancer: Targets and Therapy » Volume 11

Comparison Of Accelerated Partial Breast Radiation Therapy And External Beam Radiation Therapy By Treatment Planning Indices

Authors Hejazi P, Tirtash MJ, Khoshnazar AK

Received 18 August 2019

Accepted for publication 1 October 2019

Published 14 November 2019 Volume 2019:11 Pages 303—307


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Pranela Rameshwar

Peyman Hejazi,1 Maede Jafari Tirtash,2 Alireza Khoshbin Khoshnazar3

1Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran; 2Department of Radiotherapy, Mirdamad Oncology and Radiotherapy Center, Gorgan, Iran; 3Department of Biochemistry and Medical Physics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

Correspondence: Alireza Khoshbin Khoshnazar
Department of Biochemistry and Medical Physics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
Tel +98-9113773145

Background: Accelerated partial breast irradiation (APBI) is a method in which just bed of lumpectomy with a margin of 1–2 cm is irradiated. Regarding advantages of APBI to whole-brain radiation therapy (WBRT) and limitations for performing other techniques, we compare external beam radiation therapy (EBRT) with three-dimensional conformal radiation therapy (3DCRT), as a type of APBI technique.
Methods: Dosimetric parameters including uniformity index (UI), conformity index (CI), and homogeneity index (HI) beside heart and lung doses were assessed and compared in two techniques. CT images of 24 patients with left-sided breast cancer after lumpectomy were selected. Patients were categorized into three groups based on the volume of breast, respectively, ≤ 1000 cc, 1000–1500 cc, and ≥ 1500 cc. CI, HI, UI and DVH were calculated by DosiSoftIsogray treatment planning software.
Results: Results show the value of UI in APBI method is more than EBRT method significantly (p=0.004). Moreover, that CI in APBI method was more than EBRT (p=0.0000) and nearer to 1. There was no significant difference between HI values between APBI and EBRT methods. As the volume of breast gets bigger, HI values rise, meaning worse homogeneity.
Conclusion: APBI method may be a good method for minimizing side effect and minimizing treatment periods.

Keywords: partial radiation therapy, external beam radiation therapy, breast cancer

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]