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Comparison Of Accelerated Partial Breast Radiation Therapy And External Beam Radiation Therapy By Treatment Planning Indices

Authors Hejazi P, Tirtash MJ, Khoshnazar AK

Received 18 August 2019

Accepted for publication 1 October 2019

Published 14 November 2019 Volume 2019:11 Pages 303—307

DOI https://doi.org/10.2147/BCTT.S227686

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Professor Pranela Rameshwar


Peyman Hejazi,1 Maede Jafari Tirtash,2 Alireza Khoshbin Khoshnazar3

1Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran; 2Department of Radiotherapy, Mirdamad Oncology and Radiotherapy Center, Gorgan, Iran; 3Department of Biochemistry and Medical Physics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

Correspondence: Alireza Khoshbin Khoshnazar
Department of Biochemistry and Medical Physics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
Tel +98-9113773145
Email akhoshbin@yahoo.com

Background: Accelerated partial breast irradiation (APBI) is a method in which just bed of lumpectomy with a margin of 1–2 cm is irradiated. Regarding advantages of APBI to whole-brain radiation therapy (WBRT) and limitations for performing other techniques, we compare external beam radiation therapy (EBRT) with three-dimensional conformal radiation therapy (3DCRT), as a type of APBI technique.
Methods: Dosimetric parameters including uniformity index (UI), conformity index (CI), and homogeneity index (HI) beside heart and lung doses were assessed and compared in two techniques. CT images of 24 patients with left-sided breast cancer after lumpectomy were selected. Patients were categorized into three groups based on the volume of breast, respectively, ≤ 1000 cc, 1000–1500 cc, and ≥ 1500 cc. CI, HI, UI and DVH were calculated by DosiSoftIsogray treatment planning software.
Results: Results show the value of UI in APBI method is more than EBRT method significantly (p=0.004). Moreover, that CI in APBI method was more than EBRT (p=0.0000) and nearer to 1. There was no significant difference between HI values between APBI and EBRT methods. As the volume of breast gets bigger, HI values rise, meaning worse homogeneity.
Conclusion: APBI method may be a good method for minimizing side effect and minimizing treatment periods.

Keywords: partial radiation therapy, external beam radiation therapy, breast cancer

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