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Clinicopathological Characteristics and Survival of Small Cell Carcinoma of the Salivary Gland: a Population-Based Study

Authors Bai J, Zhao F, Pan S

Received 17 September 2019

Accepted for publication 8 November 2019

Published 24 December 2019 Volume 2019:11 Pages 10749—10757

DOI https://doi.org/10.2147/CMAR.S231446

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Ahmet Emre Eskazan


Jinbo Bai,1,* Fen Zhao,2,* Shuang Pan3

1Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People Republic of China; 2Department of Stomatology, Qilu Children’s Hospital of Shandong University, Jinan, Shandong 250022, People Republic of China; 3Department of Orthodontics, Jinan Stomatological Hospital, Jinan, Shandong 250001, People Republic of China

*These authors contributed equally to this work

Correspondence: Shuang Pan
Department of Orthodontics, Jinan Stomatological Hospital, 101 Jingliu Road, Jinan, Shandong 250001, People’s Republic of China
Email pansoral@163.com

Background: Small cell carcinoma (SmCC) of the salivary gland is rare, and the characteristics and survival are not well defined due to only case reports or case series being reported. The present study aimed to describe the clinicopathological characteristics and determine the factors associated with survival of this rare cancer.
Materials and methods: A population-based study was carried out to investigate clinical characteristics and prognosis of SmCC of the salivary gland using prospectively extracted data from the Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2016.
Results: Totally, 198 patients with SmCC of the salivary gland were identified with an average age of 72.6±12.4 and a male to female ratio of 3.4:1. The lesions of most patients (167/198) were located in the parotid gland. The median overall survival (mOS) of all patients is 25.0 months. The 1-, 3-, 5- and 10-year survival rate was 65.7%, 40.9%, 33.0% and 22.7%, respectively. Surgery could prolong significantly the mOS by almost 17.0 months (28.0 months vs 11.0 months; P<0.01). Radiotherapy, as well as radiotherapy after surgery, could prolong the mOS (PP=0.04). The survival analysis demonstrated that old age (>72 years), lymph node (N3) and distant metastases were independent factors for poor survival, whereas radiotherapy was an independent factor for favorable survival.
Conclusion: Small cell carcinoma of the salivary gland is a rare disease, and old age, lymph node and distant metastases, and radiotherapy were significantly associated with prognosis. In order to understand this disease more thoroughly, more cases with adequate information are required.

Keywords: small cell carcinoma, salivary gland, outcomes, SEER database


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