Clinicopathological characteristics and recurrence risk of papillary thyroid microcarcinoma in the elderly
Authors Wang X, Lei J, Wei T, Zhu J, Li Z
Received 16 December 2018
Accepted for publication 27 February 2019
Published 25 March 2019 Volume 2019:11 Pages 2371—2377
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Antonella D'Anneo
Xiaofei Wang, Jianyong Lei, Tao Wei, Jingqiang Zhu, Zhihui Li
Department of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, People’s Republic of China
Background: The optimal management for elderly patients with papillary thyroid microcarcinoma (PTMC) is not well established. The aim of the present study is to describe the clinicopathological characteristics and identify predictors of recurrence in the elderly PTMC patients.
Methods: We conducted a retrospective study of PTMC patients who underwent thyroidectomy. The clinicopathological characteristics were compared between patients with age ≥65 years and <65 years. The independent predictors of recurrence were identified by
multivariate Cox regression analysis.
Results: The patients in elderly group were more likely to exhibit bilaterality (P<0.050), extrathyroidal extension (P < 0.001), and central compartment lymph node metastasis (CLNM) (P<0.010), especially the ratio of CLNM >0.5 (P<0.010), than the patients with age P=0.002). Multivariate analysis indicated tumor size >5 mm (P=0.009) and CLNM ratio >0.5 (P=0.002) were independent risk factors for recurrence of the elderly patients with PTMC.
Conclusions: The elderly PTMC patients have more aggressive biological characteristics and higher recurrence rate. More aggressive treatment and rigorous follow-up could be considered for elderly patients with tumor diameter >5 mm and CLNM ratio >0.5.
Keywords: papillary thyroid microcarcinoma, recurrence, elderly
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