Clinical Pharmacology: Advances and Applications

Metabolic Syndrome and Cardiovascular Disease

Metabolic syndrome (MetS) is characterized by a constellation of metabolic abnormalities, including obesity (especially central obesity), insulin resistance, hypertension, hypertriglyceridemia, and low levels of high-density lipoprotein cholesterol (HDL-C). Each of these metabolic abnormalities represents an independent risk factor for cardiovascular disease (CVD), and their combination significantly increases the risk of a spectrum of cardiovascular conditions, including microvascular dysfunction, coronary atherosclerosis and calcification, cardiac dysfunction, myocardial infarction, and heart failure. This Article Collection highlights current knowledge pertaining to the pathophysiological mechanisms underlying MetS-associated cardiovascular entities and the clinical phenotyping of metabolic syndrome