Clinical Manifestations of Cuticular Drusen: Current Perspectives
Received 12 July 2021
Accepted for publication 9 September 2021
Published 21 September 2021 Volume 2021:15 Pages 3877—3887
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Scott Fraser
Serena Fragiotta,1 Pedro Fernández-Avellaneda,2 Mark P Breazzano,3 Gianluca Scuderi1
1NESMOS Department, Ophthalmology Unit, St. Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy; 2Department of Ophthalmology, Basurto University Hospital, Bilbao, Spain; 3Wilmer Eye Institute, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, UA
Correspondence: Serena Fragiotta
NESMOS Department, Ophthalmology Unit, St. Andrea Hospital, University of Rome “La Sapienza”, Via di Grottarossa 1035-1039, Rome, 00189, Italy
Tel +39 3293276433
Fax +39 0633776628
Email [email protected]
Abstract: Cuticular drusen are part of the spectrum of age-related macular degeneration (AMD) with particular clinical and multimodal imaging characteristics. This drusen subpopulation shares several high-risk single nucleotide polymorphisms with AMD. Despite this feature, they can manifest at a relatively young age, presenting with a female preponderance. Multimodal imaging is essential for characterizing such lesions, using a combination of color fundus photographs, optical coherence tomography (OCT), fluorescein angiography (FA), and fundus autofluorescence (FAF). The classic starry-sky pattern visible on FA and the typical central hypoautofluorescent lesion with hyperautofluorescent rim on FAF is considered the result of a central retinal pigment epithelium (RPE) erosion from these triangular elevations of the RPE-basal lamina. This finding may also be responsible for the typical choroidal hypertransmission appreciated through OCT. The clinical course of cuticular drusen may be relatively benign at early stages, with small drusen presenting at a young age. However, the presence of clinical phenotypes characterized by diffuse involvement and/or accompanying large drusen in patients older than 60 years may confer a significant risk for either macular neovascularization or geographic atrophy.
Keywords: cuticular drusen, spectral-domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, multimodal imaging
Gass first described cuticular drusen in 1977 as small round yellow subretinal lesions, which appear hyperfluorescent during the arteriovenous phase of fluorescein angiography (FA), characteristically resembling “stars-in-the-sky”.1 These alterations were initially thought to represent nodular thickening of the basement membrane of the retinal pigment epithelium (RPE), and thus named “basal laminar drusen”.2 Later, the histopathological correlation demonstrated that basal laminar drusen share with conventional drusen the localization between RPE-basal lamina (BL) and Bruch’s membrane (BrM).3 Therefore, the term “cuticular” drusen was preferred to connotate a similar ultrastructure to conventional drusen.2,4,5 Although sharing a similar content with hard drusen, cuticular drusen are numerous and tend to coalescence, resulting in a peculiar diffuse distribution.6
Major advances in multimodal imaging have permitted an accurate characterization of the cuticular drusen, identifying imaging criteria that allow a distinction with other drusen subtypes. In particular, the size and spatial density of cuticular drusen can be quantified with greater precision through imaging techniques compared to clinical examination.6 The multimodal recognition has elucidated the natural course, prognosis, and macular complications associated with cuticular drusen.7,8 In fact, similar to soft drusen, cuticular drusen exhibited a dynamic lifecycle with growth, coalescence and resorption leading to RPE abnormalities and subsequent development of macular complications.6,9–11
The present review aims to provide a comprehensive overview of the existing literature on the wide spectrum of clinical manifestations associated with cuticular drusen in age-related macular degeneration (AMD), offering insights into clinical characteristics, multimodal characterization, phenotypes, natural course, and prognosis of cuticular drusen.
Clinical Aspects of Cuticular Drusen
Demographic Characteristics and Genetic Factors
Cuticular drusen are present in the spectrum of AMD in most cases, sharing clinical features and complications. However, the relatively younger age and female preponderance are demographic features that characterize this population, divergent from typical AMD.6,7,12 Overall, the female prevalence varied from 60 to 92.1% in the cuticular population, particularly when accompanied by macular complications.6,7,13 Patients with a confirmed diagnosis of cuticular drusen were five times more likely to be female.14 The female preponderance in the cuticular subgroup seems to be peculiar considering the absence of gender difference both in early and late AMD found in large cohort studies.15,16
Genetic risk factors have been poorly investigated, but a strong association with single nucleotide polymorphism on the CFH gene (p.Tyr402His) has been reported in patients with the cuticular phenotype of drusen.17 However, the frequency of the CFH Y402H alleles in eyes presenting with a vitelliform detachment associated with cuticular drusen was similar to the general population, suggesting a distinct clinical entity.18
Genetic variants of the CFH gene were identified in 8.8% of patients with cuticular drusen subtype of AMD, and patients carrying rare CFH variants presented an earlier age at onset. Moreover, a rare missense variant p.Arg1210Cys was putatively identified as specific for the cuticular phenotype.19 Mutations in the fibulin-5 gene (FBLN5), coding for an extracellular matrix protein at the level of Bruch’s membrane, have been also associated with cuticular drusen.20,21
The estimated frequency of histidine allele at the Tyr402His locus was 70% in AMD patients with cuticular drusen, which was higher than the conventional AMD cohort (55%), corroborating a primary role of the complement cascade in the pathogenesis of this drusen subtype.13
Cuticular drusen population shared with AMD several high-risk single nucleotide polymorphisms, including rs1410996 (CFH), rs10490924 (ARMS2), rs4151667 (CFB), rs9332739 (C2), rs2230199 (C3), rs7412 (APOE E2), and rs429358 (APOE E4). This observation suggests a possible common genetic background between these AMD subtypes.22
Membranoproliferative Glomerulonephritis (MPGN)
Beyond the spectrum of AMD, cuticular drusen have been described in association with membranoproliferative glomerulonephritis (MPGN) type II. This rare form of chronic glomerulonephritis usually affects children and its clinical course is characterized by rare remissions and progression to end-stage renal disease.23
Characteristically, the ultrastructural findings include the accumulation of intramembranous osmiophilic dense deposits at the level of lamina densa of the glomerular basement membrane, and similar deposits, can accumulate at the level of the choriocapillaris—Bruch’s membrane—retinal pigment epithelium in the affected individuals.23,24
Drusen-like deposits resembling cuticular drusen were observed in all the subjects with long-standing MPGN disease (>16 months). The deposits are barely observed on clinical examination and well-visualized on the arteriovenous phase of fluorescein angiography. Along with MPGN progression over time (>15 years), retinal findings can exhibit further complications including atrophy of the retina and RPE as well as macular neovascularization.25 Similar findings were also associated with C3 glomerulonephritis, corroborating abnormalities in the the complement pathway for the pathogenesis of drusen in the context of complement-mediated glomerular diseases.26
Clinical Appearance and Diagnostic Criteria
Cuticular drusen appear clinically as a myriad of roundish yellow lesions, clustering in the macular region and/or mid-peripheral retina. They typically measure between 50 and 75 μm in diameter.1,8,12
Nevertheless, the clinical appearance alone is not distinctive enough to differentiate with other drusen subtypes. Particularly when located preferentially in the peripheral retina, they can be mistaken with hard drusen, or if they grow and coalesce can be misinterpreted as soft drusen.8,27
Based on topographical distribution, cuticular drusen have been distinguished into three phenotypes:7
Phenotype 1: clusters of numerous lesions concentrated in the macular region and occasionally extending beyond vascular arcades and peripapillary region.
Phenotype 2: lesions scattered around the posterior pole, extending into the peripheral retina and nasally past the optic nerve.
Phenotype 3: mixed type associated with large drusen (>200 μm), likely representing hyalinized or large colloid drusen.
Diagnostic criteria were proposed based on multimodal imaging observations that assist in accurate differentiation from other similar drusen phenotypes.6,7 A diagnosis can be made using at least three of four imaging methods, including color fundus photographs, spectral-domain optical coherence tomography (SD-OCT), FA, and fundus autofluorescence (FAF).6
Multimodal Characterization of Cuticular Drusen
Multimodal imaging characteristics probably reflect the internal composition of these drusen subtypes. Features of different subtypes distinguished by multimodal imaging are summarized in Table 1.
Table 1 Multimodal Imaging Characteristics of the Different Drusen Subtypes
Clinical examination alone is not sufficient to reveal cuticular drusen, especially in the early stages with subtle lesions exhibiting poor contrast. FAF can instead detect these drusen prior to eruption through the RPE. The classic FAF pattern is characterized by a central hypoautofluorescence with a hyperautofluorescent rim (Figure 1).6,28
The central RPE attenuation in these drusen is mainly localized at the apex with normal thickening at the drusen edge. Thus, less pigment blocks the excitation wavelength, and explains this produced typical FAF pattern.8 A limitation when interpreting FAF is media opacity, for example, lenticular nuclear sclerosis, which may obstruct visualization of FAF details. Consequently, cuticular drusen have been correctly identified as present in 62% of cases and not present in 100% of cases.14 In this regard, the use of a long-wavelength excitation (530–580 nm) can potentially minimize autofluorescence from the lens and increase the ability to detect heterogeneity in foveal autofluorescence due to RP/E alterations.29
Confocal scanning laser ophthalmoscopy (cSLO) with real-time tracking improves the visualization of drusen-containing regions allowing an integrated approach with OCT b-scan. The main advantages in using a cSLO FAF (488 nm) reside in the diffuse availability and the simultaneous integration with other imaging techniques as color fundus photography, FA, and SD-OCT.29,30
Fluorescein Angiography and Indocyanine Green Angiography
The typical appearance of cuticular drusen is represented by the “starry-sky” pattern characterized by several roundish hyperfluorescent lesions during the arteriovenous phase.1 These lesions remained hyperfluorescent for the entire duration of the FA, slowly fading through the very late phases (Figure 2). Meanwhile, indocyanine green angiography (ICGA) showed early hyperfluorescent lesions surrounded by faint hypofluorescent halos becoming intensely hyperfluorescent in the late ICGA phase.30 Of note, in about 50% of cases, the ICGA could not demonstrate drusen appearance despite detection with other imaging methods.6
The “starry-sky” pattern can account for the central RPE erosion with multiple associated window defects. In the early stages, when the RPE is intact, the “starry-sky” appearance may not be visible by FA.28 However, dye-based angiography techniques (FA and/or ICGA) are usually performed if deemed clinically necessary to exclude neovascularization7 and thus not to provide a primary source of drusen characterization.
Optical Coherence Tomography (OCT) Signatures
On OCT B-scans, cuticular drusen demonstrate triangular elevations of the RPE-BL with bases lying on Bruch’s membrane and apices toward the retina, conferring a characteristic “saw-tooth” pattern. In addition, the thinnest RPE apex may account for the typical hypertransmission in correspondence of the drusen center and light attenuation at the edges (Figure 3).8,31
However, the saw-tooth pattern should not be considered pathognomonic, as it is not discernible in all cases. For this reason, Balaratnasingam et al6 identified three distinct patterns seen on OCT B-scans as categorized below:
- Type 1 pattern (33%)—shallow RPE-basal lamina (BL) elevations without a clear discernible drusen content.
- Type 2 pattern (49%)—the classical saw-tooth configuration with a hyporeflective internal content.
- Type 3 pattern (18%)—broad, mound-shaped RPE-BL elevations with hyporeflective internal content.
Cuticular Drusen Lifecycle
Cuticular Drusen and Other Drusen Subtype
Large drusen (>200 μm), embodying the type 3 pattern according to Sakurada et al7 classification, variably accompanied cuticular drusen in 25–59.3% of cases (Figure 4).32,33 The presence of large drusen was often accompanied by pigmentary abnormalities in patients aged older than 60 years.6 It has been proposed that large colloid drusen may constitute a variant of cuticular drusen, but further studies are necessary to confirm this hypothesis.7
Large colloid drusen, also known as multifocal serous retinal pigment epithelium detachment by Gass, presented a similar clinical appearance of soft drusen and serous pigment epithelial detachment.34,35 Despite this, the histopathological findings demonstrated the absence of basal linear and basal laminar deposits, calcification of Bruch membrane, and thickening of the choriocapillaris walls. However, a small focus of choroidal neovascularization with evidence of exudation has been demonstrated on histopathological evaluation.34
Although rare, cuticular drusen may present in association with subretinal drusenoid deposits (SDD, also known as reticular pseudodrusen).36
Upon functional analysis, cuticular drusen present with similar retinal sensitivity values to soft and reticular pseudodrusen/SDD on both mesopic and dark-adapted red conditions, while the dark-adapted cyan condition demonstrated a significantly lower sensitivity for reticular pseudodrusen/SDD with respect to cuticular drusen. A dark-adapted cyan mean defect exceeding the dark-adapted red defect suggested a predominant rod dysfunction in reticular pseudodrusen. At the same time, the positive cyan-red difference for cuticular drusen indicated an isolated foveal cone dysfunction.37
Vitelliform Detachment Associated with Cuticular Drusen
One of the first clinical associations described for cuticular drusen was the vitelliform macular lesion.2 Patients with the combination of vitelliform macular detachment and cuticular drusen were younger and presented with worse visual acuity when compared with adult-onset vitelliform macular dystrophy.38 The prevalence of acquired vitelliform lesions in patients with cuticular drusen varied by ethnic group from 1.2% in the Asian population to 24.2% in Caucasians.6,32
These lesions are usually bilateral, characterized by a myriad of drusen producing the typical “starry-sky” appearance, accompanied by a late hyperfluorescence, likely representing the late staining of the vitelliform material (Figure 5).39 The vitelliform macular detachment on OCT appears as hyperreflective subretinal material with an overlying hyporeflective space, thus conferring the pseudohypopyon appearance in some cases.30,38
The fate of vitelliform detachment associated with cuticular drusen includes collapse with resolution of the vitelliform material and accompaniment of progressive RPE failure and atrophy with drusen disappearance. Moreover, the lesions may lead to development of macular neovascularization (MNV) among 30% of cases, which can be ill-defined through fluorescein angiography in half of these due to diffuse accumulation of fluorescein in late phases.38,40 Long-term vitelliform detachment can progressively affect photoreceptors and RPE atrophy accompanied by the resorption of vitelliform material and progressive choroidal thinning. However, the formation of vitelliform material may modulate the choroidal vasculature thickness with hyperpermeability in the early vitelliform stages, before atrophic changes have developed.41–43
Late-stage Macular Complications
Macular Neovascularization (MNV)
MNV has been detected in 12.5% of cases, among these 76.7% included type 1 neovascularization, while the remaining cases were mixed type 1 and 2 lesions.6 Interestingly, phenotypes 2 and 3 presented a higher risk for the development of MNV, which has been hypothesized to be related to the greater drusen volume than phenotype 1.7 Of note, MNV is more frequent in patients older than 60 years, although it can occur earlier in life.6,44
Other types of neovascularization have rarely been observed with only few reports so far.7,45,46 A case from a 65-year-old Japanese woman presenting with the typical “stars-in-the-sky” exhibited a type 3 neovascularization lesion.45 Another case of a 61-year-old woman of European descent demonstrated bilateral aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy) in an extrafoveal location along vascular arcade in one eye and the nasal mid-periphery in the fellow eye. Of note, the neovascular lesions co-localized with the drusen distribution that were scattered around the posterior pole, occupying the periphery and retina nasal to the optic nerve, and thus configured cuticular drusen phenotype 2.7,46 Type 2 neovascularization associated with cuticular drusen was diagnosed in only one case in a type 2 MNV cohort with an overall prevalence of 4.3%.47
Cuticular drusen exhibit dynamic change with growth and coalescence and regression accompanied by RPE alterations like conventional drusen. Drusen loads, represented by the high number of lesions that may aggregate in some cases, may contribute to the development of RPE pigmentary changes and GA.6,48,49 However, some areas in the fundus can also demonstrate a spontaneous resolution of the drusen, resulting in small defects or “imprint” of the RPE.7
Geographic atrophy (GA) occurred in 18.5–25% of cases, more frequently in patients >60 years old.6,7,32 However, 9.2% developed GA among patients 60 years of age or younger.6 Like MNV, phenotypes 2 and 3 presented a greater five-year estimated incidence of GA of 38.7% and 43.6%, respectively, compared to phenotype 1 (12.9%).7
Cuticular drusen represent a phenotype of clinical relevance in the spectrum of AMD. These lesions can occur at a younger age than conventional drusen, demonstrating a female preponderance. Therefore, multimodal characterization is essential for accurate drusen phenotyping. In fact, cuticular drusen may coexist with large drusen (>200 μm) or large colloidal drusen, resulting from coalescence or growth of typical cuticular drusen, but this needs to be proven.
The presence of cuticular drusen at early stages may be deemed a relatively benign phenomenon, but some additional factors should be considered. In young patients, the co-occurrence of vitelliform lesions can complicate the prognosis for the development of macular complications at a relatively early age. In addition, the presence of phenotypes 2 and 3 in patients older than 60 years may confer a significant risk for either MNV or GA.
The increasing recognition of cuticular drusen made possible by multimodal imaging is essential for identifying patients at risk of developing macular complications at a relatively young age. Macular complications are connected to diffuse RPE disturbances, influenced by drusen dynamic changes and drusen load, varying from vitelliform detachment to classic late-stage complications.
The authors report no conflicts of interest in this work.
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