Back to Journals » Neuropsychiatric Disease and Treatment » Volume 15

Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders

Authors Li HH, Xu ZD, Wang B, Feng JY, Dong HY, Jia FY

Received 15 April 2019

Accepted for publication 12 August 2019

Published 26 August 2019 Volume 2019:15 Pages 2443—2450


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Yuping Ning

Hong-Hua Li,1 Zhi-Da Xu,1,2 Bing Wang,1 Jun-Yan Feng,1 Han-Yu Dong,1 Fei-Yong Jia1,3

1Department of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands; 3Neurological Research Center of the First Hospital of Jilin University, Changchun, People’s Republic of China

Correspondence: Fei-Yong Jia
Department of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China
Tel +86 04 318 878 3846
Email [email protected]

Purpose: Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs.
Patients and methods: In total, 120 children with CTDs and 140 normal controls were enrolled in this study, with 36/120 of those in the CTD group receiving vitamin D3 treatment for 3 months. The Yale Global Tic Severity Scale (YGTSS) and Clinical Global Impression of Severity of Illness (CGI-SI) were, respectively, used to evaluate the tic severity. High-performance liquid chromatography and tandem mass spectrometry were used to measure serum 25(OH)D level.
Results: Those children with CTDs exhibited significantly lower 25(OH)D levels than did healthy controls, and these reduced 25(OH)D levels were linked to increasing severity of tic symptoms. After treatment with supplemental vitamin D3, serum 25(OH)D level and scores of YGTSS total, motor tics, phonic tics, total tic, impairment, and CGI-SI improved significantly in children with CTDs without any adverse reactions.
Conclusion: Supplementation vitamin D3, given its low cost and excellent safety, may be an effective means of improving symptoms in certain children with CTDs.

Keywords: vitamin D, chronic tic disorders, 25(OH)D, dopamine, child

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]