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Clinical Approach to Linear Hyperpigmentation: A Review Article

Authors Alkhowailed MS, Otayf M, Albasseet A, Almousa A, Alajlan Z, Altalhab S

Received 7 September 2020

Accepted for publication 24 November 2020

Published 8 January 2021 Volume 2021:14 Pages 23—35

DOI https://doi.org/10.2147/CCID.S280819

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg


Mohammad S Alkhowailed,1 Mojahed Otayf,2 Abdulrahman Albasseet,2 Abdullah Almousa,2 Ziyad Alajlan,2 Saad Altalhab3

1Department of Dermatology, College of Medicine, Qassim University, Buraydah, Qassim, Saudi Arabia; 2College of Medicine, King Saud University, Riyadh, Saudi Arabia; 3Department of Dermatology, College of Medicine, Al-Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia

Correspondence: Mohammad S Alkhowailed
Department of Dermatology College of Medicine, Qassim University, Buraidah 52571, Qassim, Saudi Arabia
Email m.alkhowailed@gmail.com

Abstract: Linear hyperpigmentation is an unusual anatomical configuration in clinical dermatology. Owing to its rarity, consensus on the most effective method of classification is lacking. While linear hyperpigmentation generally follows Blaschko’s lines, this is not universal. Clinical findings such as adherence to Blaschko’s lines, associated morphological findings (including other cutaneous lesions), and systemic manifestations can be used to further characterize and diagnose variants of the disorder. Early detection of any underlying disease is vital, especially in cases with effective management, because the disorder may make it difficult to manage hyperpigmentation. Herein, we introduce a logical clinical diagnostic approach that represents a useful tool for dermatologists to efficiently evaluate patients presenting with linear hyperpigmentation. A simplified systematic and evidence-based approach is useful for this clinical condition owing to the heterogeneous causes and lack of specific diagnostic tools.

Keywords: approach, blaschkitis, Blaschko’s lines, hyperpigmentation, linear, pigmentary mosaicism

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